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. 2018 Feb 8;9(18):14193–14206. doi: 10.18632/oncotarget.24447

Table 1. Clinicopathological characteristics disaggregated by TP53 signature status.

Total Mutant type Wild type
No. of patients % No. of patients % No. of patients % P*
Samples 174 100 64 37 110 63
Age, years (median) 26–98 (58.0) 37–83 (58.5) 26–98 (57.0) 0.233
pStage
 I 85 49 24 39 61 58
 IIA 59 34 28 43 31 28
 IIB 30 17 12 19 18 16 0.058
ER
 Positive 124 71 28 44 96 87
 Negative 50 29 36 56 14 13 <0.001
PgR
 Positive 95 54 16 25 79 72
 Negative 79 46 48 75 31 28 <0.001
HER2
 Positive 16 9 12 19 4 4
 Negative 158 91 52 81 106 96 0.002
Pathological tumor size, cm
 T1 112 64 39 61 73 66
 T2 60 35 25 39 35 32
 T3 2 1 0 0 2 2 0.374
Node
 Positive 55 32 25 39 30 27
 Negative 119 68 39 61 80 73 0.149
Grade
 1 43 26 3 5 40 38
 2 74 44 19 30 55 52
 3 51 30 41 65 10 1 <0.001
Adjuvant chemotherapy
 + 77 44 42 66 35 35
 − 97 56 22 34 75 65 <0.001
Adjuvant Endocrine therapy
 + 123 71 25 39 98 89
 − 51 29 39 61 12 11 <0.001

Abbreviations: pStage, pathological stage; ER, estrogen receptor; PgR, progesterone receptor; HER2, human epidermal growth factor receptor type 2.

P*: Chi-square test was used for statistical analysis of patients' characteristics except for age.

Kruskal–Wallis test was used for statistical analysis of patients' age.