Table 1. Clinicopathological characteristics disaggregated by TP53 signature status.
Total | Mutant type | Wild type | |||||
---|---|---|---|---|---|---|---|
No. of patients | % | No. of patients | % | No. of patients | % | P* | |
Samples | 174 | 100 | 64 | 37 | 110 | 63 | |
Age, years (median) | 26–98 (58.0) | 37–83 (58.5) | 26–98 (57.0) | 0.233 | |||
pStage | |||||||
I | 85 | 49 | 24 | 39 | 61 | 58 | |
IIA | 59 | 34 | 28 | 43 | 31 | 28 | |
IIB | 30 | 17 | 12 | 19 | 18 | 16 | 0.058 |
ER | |||||||
Positive | 124 | 71 | 28 | 44 | 96 | 87 | |
Negative | 50 | 29 | 36 | 56 | 14 | 13 | <0.001 |
PgR | |||||||
Positive | 95 | 54 | 16 | 25 | 79 | 72 | |
Negative | 79 | 46 | 48 | 75 | 31 | 28 | <0.001 |
HER2 | |||||||
Positive | 16 | 9 | 12 | 19 | 4 | 4 | |
Negative | 158 | 91 | 52 | 81 | 106 | 96 | 0.002 |
Pathological tumor size, cm | |||||||
T1 | 112 | 64 | 39 | 61 | 73 | 66 | |
T2 | 60 | 35 | 25 | 39 | 35 | 32 | |
T3 | 2 | 1 | 0 | 0 | 2 | 2 | 0.374 |
Node | |||||||
Positive | 55 | 32 | 25 | 39 | 30 | 27 | |
Negative | 119 | 68 | 39 | 61 | 80 | 73 | 0.149 |
Grade | |||||||
1 | 43 | 26 | 3 | 5 | 40 | 38 | |
2 | 74 | 44 | 19 | 30 | 55 | 52 | |
3 | 51 | 30 | 41 | 65 | 10 | 1 | <0.001 |
Adjuvant chemotherapy | |||||||
+ | 77 | 44 | 42 | 66 | 35 | 35 | |
− | 97 | 56 | 22 | 34 | 75 | 65 | <0.001 |
Adjuvant Endocrine therapy | |||||||
+ | 123 | 71 | 25 | 39 | 98 | 89 | |
− | 51 | 29 | 39 | 61 | 12 | 11 | <0.001 |
Abbreviations: pStage, pathological stage; ER, estrogen receptor; PgR, progesterone receptor; HER2, human epidermal growth factor receptor type 2.
P*: Chi-square test was used for statistical analysis of patients' characteristics except for age.
Kruskal–Wallis test was used for statistical analysis of patients' age.