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. 2018 Feb 16;9(18):14324–14337. doi: 10.18632/oncotarget.24511

Figure 2. Relationship of BC expression of HMGA1 to the ability of SAE BC to differentiate.

Figure 2

Primary BC purified from human SAE sampled by bronchoscopic brushing of 47 individuals (17 nonsmokers, 14 healthy smokers and 16 COPD smokers). (A) HMGA1 expression evaluated by TaqMan at day 0 before differentiation on ALI culture (see Methods, BC-1 and ALI-1). Based on the data in panel A, samples were categorized as “top HMGA1” expressors (HMGA1 expression highest quartile, n = 12), and “bottom HMGA1” expressors (HMGA1 expression lowest quartile, n = 12). The data was normalized to 18S rRNA. (B) Kaplan–Meier survival analysis on ALI cultures for HMGA1-top and –bottom quartile expressors of all nonsmokers, healthy smokers and COPD smokers in SAE BC samples. p = 0.03, log-rank test.