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. 2018 Feb 16;9(18):14338–14353. doi: 10.18632/oncotarget.24512

Figure 2. Genomic, chromosomal and chromatin analyses.

Figure 2

(A) Genomic profiling was performed for seven HL cell lines. The results for chromosome 1 demonstrated absence of copy number alterations in L-540 at the locus of HLX (1q41). (B) Fluorescence in-situ hybridization (FISH) in L-540 demonstrated wild type configurations at the locus of HLX although chromosome 1 showed some structural abnormalities. We used two flanking and one spanning probe for HLX (left), and the spanning probe in combination with a painting probe for chromosome 1 (right). The clone names and the colors of the used probes are indicated. The detected loci of HLX are indicated by arrows. (C) RQ-PCR analysis of HLX was performed for HL cell line L-540 after treatment with various inhibitors.