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. 2018 Feb 16;9(18):14481–14491. doi: 10.18632/oncotarget.24520

Figure 1. Calcitriol inhibits tumor growth and reduces CSCs in mouse ovarian xenograft model.

Figure 1

(a, b) Calcitriol inhibits growth of ovarian xenografts in vivo. The ovarian cancer cell line 2008 was injected into nude mice subcutaneously to generate xenografts. After 1 week, mice were administered with either vehicle (n=8) or calcitriol dissolved in sesame oil (n=6) i.p., 0.5 μg/Kg, once a day for 7 consecutive days. Tumor size was recorded with caliber and tumor growth curves were plotted (a) Tumor images at the harvest day were shown (b). A linear mixed effect model was used to compare the tumor growth rate between two groups. **: P < 0.01. (c, d) Calcitriol reduces the CSC population in ovarian xenografts in vivo. Tumor xenografts were harvested after calcitriol treatment. Tumor cells were isolated, and the percentage of CD44+CD117+ cells in each sample was analyzed using FACS (c) and plotted (d). N = 8 for control group, and N = 6 for calcitriol group, bar: SD, **: P < 0.01.