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(A) In the absence of Shh binding to Ptch, Ptch exerts an inhibitory action on Smo. Gli is associated with SUFU in the cytoplasm and is inactive. (B) When Shh binds to Ptch, Smo is activated and induces the migration of Gli into the nucleus with subsequent activation of the transcription of target genes. Main inhibitors of the Shh pathway are also shown.
