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. Author manuscript; available in PMC: 2018 Aug 19.
Published in final edited form as: Nat Genet. 2018 Feb 19;50(3):452–459. doi: 10.1038/s41588-018-0061-8

Figure 4.

Figure 4

A shows the top 5 statistically significantly enriched GO terms within the set of genes that coevolve with DNMTs across metazoans. Terms associated with DNA repair are shown in red, others in grey. B shows the conservation of ALKB2 along with DNMTs across different taxonomic groups. Losses amongst N independent branches are shown, where N=20, metazoa; N=31, Fungi; N=23, Protists. C shows the conservation of different members of the ALKB family in nematodes with and without DNA methylation.