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. 2017 Aug 22;16(5):5915–5923. doi: 10.3892/mmr.2017.7327

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Copyright: © Dong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Overexpression of RBP4 altered the expression of related regulators and related signal pathways in HEPM cells. (A) The protein levels of RBP4, cyclin D1, PCNA, p-ERK1/2 and p-AKT were all upregulated in HEPM cells overexpressing RBP4, however p27 was downregulated compared with the Con group. The protein levels of RBP4, cyclin D1, PCNA, p-ERK1/2 and p-AKT remained upregulated in the RBP4 overexpressing group treated with atRA, and p27 was downregulated compared with the Con group. (B) The data for the protein levels are presented as the mean + standard deviation. A total of 3 duplicate samples were used in each group, and experiments were performed in triplicate. **P<0.01 and ***P<0.001. RBP4, retinol binding protein 4; HEPM, human embryonic palatal mesenchymal; PCNA, proliferating cell nuclear antigen; p-, phosphorylated; ERK, extracellular signal-related kinase; AKT, protein kinase B; atRA, all-trans retinoic acid; Con, control.