Table II.
The 122 SNPs significantly associated with atrial fibrillation by exome-wide association analysis.
| Gene | SNP | Nucleotide substitution (amino acid)a | Chromosome: Position | MAF (%) | P-value (allele) | Allele OR |
|---|---|---|---|---|---|---|
| N4BP2 | rs61748749 | T/G (S1353R) | 4: 40122170 | 2.3 | <1.0×10−255 | 0.74 |
| DNAH17 | rs690844 | A/C (I1742M) | 17: 78501838 | 2.5 | 8.94×10−255 | 1.31 |
| HELZ | rs184499441 | C/T (G1288R) | 17: 67114380 | 1.6 | 4.40×10−240 | 1.08 |
| rs7828656 | A/C | 8: 11645425 | 44.8 | 1.87×10−220 | 1.1 | |
| SLA2 | rs221308 | T/C | 20: 36647995 | 46.7 | 4.11×10−218 | 0.99 |
| SSPO | rs55976638 | G/T | 7: 149832881 | 4.3 | 2.99×10−182 | 1.31 |
| TCEB3B | rs2010834 | A/C (F254C) | 18: 47034504 | 24.5 | 2.60×10−141 | 1.1 |
| FANCL | rs149731356 | T/C (T224A) | 2: 58165745 | 0.7 | 7.35×10−130 | 0.75 |
| PIEZO1 | rs143004911 | G/A (R333C) | 16: 88737957 | 2.7 | 5.07×10−122 | 0.87 |
| TTYH2 | rs9899862 | C/A (D423E) | 17: 74253090 | 6.3 | 1.31×10−96 | 0.86 |
| TUBB3 | rs2302898 | A/G | 16: 89932386 | 23.5 | 1.13×10−87 | 0.87 |
| SLCO6A1 | rs17150488 | T/C (K381R) | 5: 102438751 | 0.6 | 3.30×10−81 | 1.05 |
| GMDS | rs9378305 | C/T | 6: 1703056 | 41.4 | 1.20×10−54 | 0.99 |
| RP1L1 | rs79329877 | T/C | 8: 10622701 | 9.2 | 2.05×10−53 | 1.05 |
| FCMR | rs150080259 | T/G (S61R) | 1: 206902976 | 1.5 | 1.07×10−49 | 1.02 |
| RTKN2 | rs7090884 | A/G | 10: 62202267 | 33.2 | 4.97×10−46 | 1.05 |
| UTP4 | rs193164904 | A/G (I534V) | 16: 69163131 | 0.2 | 1.90×10−45 | 1.58 |
| SNAPC1 | rs74810099 | T/G (M36R) | 14: 61762567 | 2.8 | 1.99×10−43 | 1.02 |
| ALPK2 | rs3809977 | G/T (P1174H) | 18: 58536666 | 17.2 | 3.05×10−42 | 0.93 |
| CSPG4 | rs137981794 | T/C (D1936G) | 15: 75676712 | 0.4 | 4.05×10−42 | ND |
| MDN1 | rs9294445 | A/G (Y3423H) | 6: 89692763 | 7.5 | 1.15×10−41 | 0.99 |
| SETD7 | rs6814310 | C/A | 4: 139534374 | 48.4 | 1.64×10−41 | 0.97 |
| PLA2G4E | rs4924595 | T/C (N400S) | 15: 41995408 | 18.2 | 1.87×10−35 | 1.01 |
| KIF7 | rs117123311 | C/G (S788R) | 15: 89642233 | 3.1 | 1.03×10−32 | 1 |
| CTBP2 | rs3781411 | C/T (R298Q) | 10: 125026867 | 7 | 1.46×10−30 | 0.9 |
| GATA2 | rs78245253 | G/C (A250P) | 3: 128485850 | 4.6 | 1.37×10−27 | 0.79 |
| DLGAP1 | rs3745051 | C/T | 18: 3729175 | 34.4 | 1.64×10−26 | 0.86 |
| rs1711393 | T/C | 4: 178074088 | 31 | 1.70×10−26 | 1.14 | |
| SLAMF7 | rs117009784 | A/C (R96S) | 1: 160750053 | 5.8 | 3.86×10−26 | 1.07 |
| USP32 | rs8079220 | C/T | 17: 60239372 | 20.5 | 3.56×10−25 | 0.91 |
| rs8011192 | T/G | 14: 28319412 | 33.1 | 8.46×10−25 | 0.99 | |
| IMPDH1 | rs201001000 | G/A (T369M) | 7: 128395003 | 0.1 | 3.85×10−24 | 0.79 |
| ADRA1A | rs151273238 | G/A (T391M) | 8: 26770378 | 0.2 | 2.12×10−23 | 0.71 |
| TNFSF13 | rs11552708 | G/A (G67R) | 17: 7559238 | 36.6 | 1.32×10−22 | 0.54 |
| SLC18A3 | rs118107581 | A/G (I426V) | 10: 49612016 | 2 | 1.62×10−22 | 1.11 |
| NFATC2 | rs12479626 | T/C (H446R) | 20: 51475656 | 4.7 | 2.79×10−22 | 1.06 |
| TENM4 | rs3812723 | C/T (V396I) | 11: 78863031 | 1.7 | 1.03×10−21 | 0.89 |
| EPN1 | rs200478642 | C/T (P203L) | 19: 55689301 | 0.1 | 1.52×10−21 | 0.35 |
| HNRNPC | rs17197037 | A/G | 14: 21257495 | 29.1 | 3.26×10−21 | 0.99 |
| TMX4 | rs2076015 | T/C (R303G) | 20: 7982394 | 41.1 | 4.49×10−21 | 1.16 |
| FOXN4 | rs140167217 | G/A (S308F) | 12: 109281778 | 0.4 | 4.51×10−19 | 1.12 |
| CEP152 | rs145138194 | G/A (S894F) | 15: 48760148 | 1.2 | 6.92×10−18 | 0.73 |
| FREM2 | rs114864077 | C/T (P128L) | 13: 38687727 | 0.1 | 1.04×10−17 | 1.81 |
| CPA6 | rs4737845 | T/C | 8: 67542707 | 43.3 | 1.87×10−17 | 1.04 |
| KIF15 | rs146292440 | G/A (R1199H) | 3: 44843135 | 0.6 | 3.33×10−17 | 0.57 |
| MFSD1 | rs3765083 | A/G (I230V) | 3: 158819654 | 30.3 | 4.19×10−17 | 1.05 |
| BAHD1 | rs3743143 | A/G (E26G) | 15: 40458541 | 10.5 | 5.85×10−17 | 0.99 |
| rs1395821 | A/G | 4: 147126398 | 39.6 | 6.48×10−17 | 1.05 | |
| BRWD1 | rs2183573 | G/A (P1511S) | 21: 39202379 | 46 | 1.11×10−16 | 1.06 |
| CD69 | rs199676648 | G/A (R32C) | 12: 9756390 | 0.3 | 2.93×10−16 | 0.9 |
| HR | rs12675375 | C/T (G337D) | 8: 22127432 | 43.4 | 8.47×10−16 | 1.02 |
| SOAT1 | rs143616084 | G/A (R292Q) | 1: 179345008 | 0.1 | 6.19×10−15 | ND |
| JMJD1C | rs149833441 | T/C (K878E) | 10: 63208491 | 1.2 | 9.49×10−15 | 1.44 |
| VWDE | rs848016 | A/G (F142S) | 7: 12389177 | 36.7 | 1.41×10−14 | 1.05 |
| VPS13D | rs143833298 | G/A (R830Q) | 1: 12276077 | 0.8 | 1.59×10−14 | 0.86 |
| SPATC1L | rs113710653 | C/T (E231K) | 21: 46161921 | 1.9 | 1.60×10−14 | 5.36 |
| SNX19 | rs117834100 | C/A (G416C) | 11: 130914694 | 6.9 | 1.83×10−14 | 0.89 |
| rs9854207 | A/C | 3: 27572825 | 40.3 | 3.41×10−14 | 1.04 | |
| ARHGAP8 | rs5766113 | A/G | 22: 44855543 | 36.8 | 7.18×10−14 | 1.03 |
| rs4407763 | G/A | 7: 67553705 | 35.8 | 1.14×10−13 | 1.08 | |
| SLC22A25 | rs11231397 | G/C (R300T) | 11: 63183749 | 43.7 | 1.53×10−13 | 1.55 |
| XIRP2 | rs77219745 | G/A (G1839D) | 2: 167246908 | 7 | 2.89×10−13 | 0.81 |
| MCM10 | rs7905784 | A/T (T541S) | 10: 13192356 | 2.2 | 5.31×10−13 | 1.05 |
| HIST1H2AC | rs198823 | G/T | 6: 26122705 | 22.9 | 1.60×10−12 | 0.86 |
| rs10102598 | G/A | 8: 47178128 | 37.7 | 1.61×10−12 | 0.96 | |
| VPS13C | rs77555508 | G/A (S1798F) | 15: 61940726 | 0.6 | 2.47×10−12 | 1.44 |
| ADCY3 | rs7586879 | C/T | 2: 24894108 | 44.7 | 1.18×10−11 | 0.99 |
| CTC1 | rs183966301 | G/A (A1025V) | 17: 8229384 | 0.2 | 1.84×10−11 | 0.56 |
| SALL4 | rs77538589 | C/T (G117R) | 20: 51792134 | 4.3 | 2.24×10−11 | 2.61 |
| ADCY7 | rs201661947 | G/A (A475T) | 16: 50304414 | 0.2 | 3.37×10−11 | ND |
| TP53INP1 | rs896854 | G/A | 8: 94948283 | 30.7 | 3.76×10−11 | 0.96 |
| TMEM245 | rs2271877 | C/T (A314T) | 9: 109091132 | 11.5 | 8.13×10−11 | 0.98 |
| FCRL1 | rs149740001 | A/T (K103I) | 1: 157803856 | 1 | 8.38×10−11 | 1.22 |
| SCYL2 | rs200554353 | T/C (M256T) | 12: 100312568 | 1.6 | 8.73×10−11 | 0.36 |
| TMCO3 | rs185071949 | C/T (P14L) | 13: 113495622 | 0.4 | 1.97×10−10 | 1.02 |
| WDR27 | rs3734905 | C/T | 6: 169558886 | 19.5 | 3.00×10−10 | 0.99 |
| NGB | rs117207261 | C/G (Q60E) | 14: 77269238 | 0.5 | 3.59×10−10 | 1.24 |
| rs6695567 | A/G | 1: 53163913 | 43.6 | 4.89×10−10 | 1.05 | |
| FAP | rs151314911 | C/T | 2: 162173786 | 2.9 | 5.26×10−10 | 1.02 |
| rs13277113 | A/G | 8: 11491677 | 31.9 | 5.36×10−10 | 1.01 | |
| ACER1 | rs72981971 | T/C (M74V) | 19: 6312279 | 36.5 | 5.41×10−10 | 1 |
| FREM2 | rs2496425 | T/C (F1070S) | 13: 38690553 | 38.3 | 7.29×10−10 | 1.01 |
| ASB13 | rs138695721 | A/C (V139G) | 10: 5649071 | 0.6 | 7.67×10−10 | 1.09 |
| rs10943716 | T/C | 6: 80543356 | 40.2 | 1.05×10−9 | 1.05 | |
| CCDC168 | rs1449707 | A/G (I3015T) | 13: 102741653 | 44.4 | 1.82×10−9 | 0.98 |
| ADGRV1 | rs2366928 | A/G (K3471E) | 5: 90728918 | 17.9 | 2.17×10−9 | 0.97 |
| MDN1 | rs115931523 | G/A (T3130M) | 6: 89695987 | 0.2 | 2.44×10−9 | 1.58 |
| CD96 | rs140727933 | A/G (Y11C) | 3: 111542280 | 0.2 | 2.63×10−9 | 1.16 |
| rs4965121 | G/C | 15: 97975562 | 8.5 | 2.69×10−9 | 0.97 | |
| KNL1 | rs11858113 | T/C (M598T) | 15: 40621979 | 27.4 | 3.29×10−9 | 0.99 |
| OR4X2 | rs7120775 | C/G (Y27*) | 11: 48245184 | 16.9 | 3.65×10−9 | 1.05 |
| TRPM2 | rs144412484 | A/G (E450G) | 21: 44390934 | 0.4 | 3.68×10−9 | 0.82 |
| MGAT5 | rs66523341 | C/T | 2: 134364804 | 37 | 4.17×10−9 | 0.93 |
| GCOM1 | rs4774980 | G/A | 15: 57691677 | 6 | 5.40×10−9 | 0.98 |
| CSMD2 | rs1874045 | T/C (K2096R) | 1: 33605925 | 45.1 | 7.56×10−9 | 1.08 |
| ADAT1 | rs200524721 | G/C (Q167H) | 16: 75612785 | 0.3 | 8.75×10−9 | 1.12 |
| rs4420065 | T/C | 1: 65695778 | 13.1 | 1.52×10−8 | 1.02 | |
| NLRX1 | rs149129258 | C/A (P262Q) | 11: 119174034 | 0.5 | 2.31×10−8 | 0.99 |
| DNAAF3 | rs890871 | A/G (L280P) | 19: 55160687 | 25.2 | 3.01×10−8 | 0.98 |
| ZNF25 | rs150582814 | T/C (Y202C) | 10: 37952893 | 0.1 | 3.01×10−8 | ND |
| CMYA5 | rs62621915 | C/T (L1038F) | 5: 79731877 | 49.3 | 5.62×10−8 | 0.93 |
| SYDE2 | rs141587551 | C/A (D173Y) | 1: 85200480 | 6.6 | 6.20×10−8 | 1.03 |
| SLC15A5 | rs3915247 | C/T | 12: 16247679 | 47.6 | 7.01×10−8 | 0.97 |
| CDC42BPG | rs3741395 | T/C (Q1135R) | 11: 64830034 | 5.6 | 8.31×10−8 | 1.11 |
| rs8030485 | G/A | 15: 79116590 | 35.2 | 9.03×10−8 | 0.98 | |
| rs2564486 | G/T | 18: 59579061 | 12.9 | 9.24×10−8 | 1.05 | |
| SLC4A4 | rs1062677 | A/C (I1074L) | 4: 71567828 | 6.1 | 1.20×10−7 | 0.91 |
| STEAP1B | rs17364464 | A/G | 7: 22474434 | 12.2 | 2.03×10−7 | 0.99 |
| KLF17 | rs11210969 | T/A (I35N) | 1: 44129375 | 22.5 | 2.83×10−7 | 1.11 |
| ADAMTS13 | rs78977446 | C/T (S903L) | 9: 133445796 | 4.5 | 3.10×10−7 | 1.24 |
| ZNF879 | rs17078988 | A/G (T112A) | 5: 179032282 | 33.8 | 4.42×10−7 | 1.01 |
| rs1464833 | T/C | 7: 125475608 | 10.2 | 4.58×10−7 | 1.01 | |
| PKD1L1 | rs10951936 | A/T | 7: 47882084 | 21 | 7.76×10−7 | 1.01 |
| SNX32 | rs200684568 | G/A (G179R) | 11: 65850787 | 0.5 | 9.00×10−7 | 0.56 |
| NTF3 | rs6332 | G/A | 12: 5494466 | 41.8 | 9.12×10−7 | 1.09 |
| EFHD1 | rs4072149 | T/C | 2: 232643967 | 36.7 | 9.18×10−7 | 1.01 |
| URB2 | rs3811473 | G/T (G778V) | 1: 229636946 | 15.8 | 9.48×10−7 | 1.05 |
| CCDC71 | rs4955419 | A/T (Q317L) | 3: 49163259 | 4.6 | 9.91×10−7 | 1.13 |
| rs543588 | T/G | 13: 30096848 | 31.4 | 1.01×10−6 | 0.9 | |
| TRIM40 | rs757259 | G/A (E244K) | 6: 30147765 | 16 | 1.06×10−6 | 1.12 |
| rs3129264 | T/C | 6: 33133825 | 8.3 | 1.07×10−6 | 0.8 | |
| SEMA6A | rs12516652 | G/T (D567E) | 5: 116475552 | 1.9 | 1.14×10−6 | 1.2 |
Allele frequencies were analyzed with Fisher's exact test. P<1.21×10−6 was considered to indicate a significant association.
a
Major allele/minor allele. SNP, single nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio; ND, not determined. SNPs without gene names are not located within the genes.