Table IV.

P-values of the association between SNPs and intermediate phenotypes of atrial fibrillation.

SNP	Nucleotide substitution (amino acid)	Hypertension	DM	Hyper-TG	Hypo-HDL	Hyper-LDL	CKD	Obesity	HU
rs11552708	G/A (G67R)	0.9943	0.7439	0.8296	0.0622	0.8902	0.0754	0.472	0.0006
rs113710653	C/T (E231K)	0.1278	0.5273	0.1465	0.6862	0.2732	0.4215	0.9986	0.1295
rs11231397	G/C (R300T)	0.2471	0.9445	0.12	0.1683	0.9415	0.9571	0.1993	0.9519
rs77538589	C/T (G117R)	0.1179	0.8113	0.4675	0.6656	0.5844	0.8815	0.8741	0.6006

The prevalence of each phenotype was compared among genotypes with Fisher's exact test (2×2) or Pearson's chi-square test (2×3). Based on Bonferroni's correction, P<0.0016 (0.05/32) were considered statistically significant and are shown in bold. SNP, single nucleotide polymorphism; DM, diabetes mellitus; hyper-TG, hypertriglyceridemia; hypo-HDL, hypo-high density lipoprotein-cholesterolemia; hyper-LDL, hyper-low density lipoprotein-cholesterolemia; CKD, chronic kidney disease; HU, hyperuricemia.