Figure 5.

GSKI treatment attenuates LPS-induced pulmonary inflammation. LPS-challenged mice were treated with GSKI 30 min following LPS challenge, and pro-inflammatory cytokines and chemokines in bronchoalveolar lavage fluid were determined on day 3. Data are presented as the mean ± standard deviation of one experiment consisting of three replicates. *P<0.05; and **P<0.01. GSKI, glycogen synthase kinase-3β inhibitor; LPS, lipopolysaccharide; ARDS, acute respiratory distress syndrome; IL, interleukin; TNF-α, tumor necrosis factor-α.