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. 2017 Sep 7;16(5):6736–6742. doi: 10.3892/mmr.2017.7436

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Expressions levels of (A) LOX, (B) MMP-2 and (C) MMP-9 in rats of the synovial membrane of the control group (C), model group (M) and intervention group (I), as determined by immunohistochemical staining. Following establishment of the CIA model, the expressions levels of LOX, MMP-2 and MMP-9 in the synovial membranes were increased compared with those in the control group. However, following inhibition of LOX with BAPN, the expression levels of MMP-2 and MMP-9 were decreased significantly compared with those in (D) the model group. Data are presented as the mean ± standard deviation. LOX, lysyl oxidase; MMP, matrix metalloproteinase; CIA, collagen-induced arthritis; BAPN, β-aminopropionitrile.