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. 2017 Sep 5;16(5):6780–6786. doi: 10.3892/mmr.2017.7428

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Copyright: © Ribeiro et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Genes associated to diverse biological processes with impact on cancer development according to UCSC genome browser. The percentage represents the number of genes associated with each biological process. (A) Genes identified specifically in leukoplakia of patient 1. The following genes are associated only with one specific biological process: DNA repair: C11orf30, CHAF1B, GTF2H1, POLD3, RNF169. Apoptosis/cell death: ANO1, BIRC6, BNIPL, DAP3, MCL1, SAP30BP, SUMO2, PAK2, PTRH2. Cancer: SERPINH1, STAG2, TRIM37, WNT11, GSTT1, PPME1, PRUNE. Cell cycle: CCNO, COPS5, CSPP1. Invasion/migration: LLGL2, RAB25. Tumor suppressor: ZNRF3. X-ray radiation: XRRA1. (B) Genes identified specifically in erythroleukoplakia of patient 2. The following genes are associated only with one specific biological process: DNA repair: KIAA0146, MCM4, NSMCE2, PRKDC, RNF168, SF3B3, SIRT6, UIMC1, XRCC2, XRCC6. Apoptosis/cell death: ATAD5, BAX, BBC3, BCL2L13, BNIPL, CARD8, HCHD2, DAPK3, GRINA, IFI6, MAP15, MCL1, PYCARD, RDM25, RERE, TAOK2, TMEM161A, TRADD, TRIAP1. Angiogenesis: CCR10. Cancer: ALDH2, CREB3L3, CTCF, OX6C, DPP9, DUSP22, ELAVL1, EWSR1, FAM83A, GAL3ST1, HIGD1B, MDM2, MTSS1, NQO1, PGPEP1, PIK3CB, POUSF1B, PRDX1, PRDX2, PVT1, RFX1, RNF139, RPS15, RPS8, S100PBP, SAFB, SELENBP1, SPIN1, WWP2. Proliferation: ANGPTL6, CIB1, DLG1, HDGFRP3, FUT3, PLA2G1B, RASL10A, S1PR2. Cell cycle: ARID3A, BRD4, CDK2AP1, CSPP1, FZR1, GADD4SGIP1, NAE1, NPEPPS, PPP6C. Invasion/migration: ELMO3, MRI1, PARD6A, SCAI, ZRANB1. Cell growth: ARHGEF18, CD37, CDIPT, DDX19B, DDX20, DDX28, PPAN-P2RY11, PTK2, SESN2. Tumor suppressor: ADAM11, APC2, MAPKAPK5, ZNRF3. Tumor growth: ANXA13, KLF10, PDF. Differentiation: PUM1.