Table I.
Chromosomal regions described in the study of Van den Broek et al (29), as associated with chemoradioresistance and chemoradiosensitivity and some putative candidate genes for these regions identified in the patient 2.
| Chromosomal region | Type of alteration | Clinical association | Patient 2-tumor | Patient 2-non-tumor | Patient 2-leukoplakia | Putative candidate genes |
|---|---|---|---|---|---|---|
| 3q21-q26.1 | Gain | Chemoradioresistance | 3q25.32 | |||
| 6p11-pter | 6p25.3 | 6p25.3; 6p23-p22.3 | DUSP22, JARID2 | |||
| 6q22-q27 | 6q22.1 | 6q22.1 | ||||
| Xq11-qter | Xq11.1 | Xq11.1 | ||||
| Xq25 | Xq25 | |||||
| 7p11.2–12 | Amplification | 7p11.2 | SEPT14, CHCHD2 | |||
| 8p11.1–12 | 8p11.22 | 8p11.22 | 8p11.22 | |||
| 12q15 | 12q15 | RAP1B, MDM2 | ||||
| 15q21 | 15q21.2 | |||||
| 18p11.3 | 18p11.32 | 18p11.32 | 18p11.32 | |||
| 3p11-pter | Loss | 3p14.2-p14.1 | FHIT, PTPR6, ADAMTS9 | |||
| 5q11-q12 | Gain | Chemoradiosensitivity | 5q11.2 | |||
| 10q11-q22 | 10q11.22 | 10q11.22 | 10q11.22; 10q11.21 | |||
| 14q distal | 14q32.33 | 14q32.33 | 14q32.33 | |||
| 14q13 | Amplification | 14q13.1-q13.2 | EAPP | |||
| 2q22-q25 | Loss | 2q23.3-q24.1 |