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. 2017 Sep 21;16(5):7229–7236. doi: 10.3892/mmr.2017.7569

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Effect of DhHP-6 on cerebral ischemia induced by 2 h of middle cerebral artery occlusion and 22 h of reperfusion. (A) Triphenyltetrazolium chloride staining of coronal brain sections 22 h following reperfusion. Infarct brain tissues appeared unstained. Tissues in the I/R+DH group, but not the I/R+DL group, demonstrated significant reductions in (B) infarct volume, (C) neurological deficits and (D) brain edema, in a dose-dependent manner. Data are shown as the mean ± standard deviation. One-way analysis of variance and Tukey's post hoc test were performed. ^###P<0.001 and ^##P<0.01, vs. Sham group; *P<0.05, vs. I/R group (n=10). I/R, ischemia/reperfusion; DhHP-6, deuterohemin His peptide-6; DH, 1 mg/kg/day DhHP-6; DL, 0.1 mg/kg/day DhHP-6.