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. 2017 Sep 21;16(5):7229–7236. doi: 10.3892/mmr.2017.7569

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effects of DhHP-6 on the rate of cytochrome c release and the activation of caspase-3 22 h post-reperfusion. The contents of cytochrome c in the subcellular fractions were examined using western blot analysis. (A) The ratio of cytochrome c content in the cytosolic and mitochondrial fractions was increased significantly in the I/R group, but the ratio was decreased markedly in the I/R+DH group. (B) Additionally, the expression level of cleaved caspase-3 was increased in the I/R group at 22 h post-reperfusion, but significantly decreased in the I/R+DH group, compared with the I/R group. Data are shown as the mean ± standard deviation. One-way analysis of variance and Tukey's post hoc test were performed. ^###P<0.001 and ^##P<0.01, vs. Sham group; *P<0.05, vs. I/R group (n=3). DhHP-6, deuterohemin His peptide-6; DH, 1 mg/kg/day DhHP-6; DL, 0.1 mg/kg/day DhHP-6; mito, mitochondria; cyto, cytosol; I/R, ischemia/reperfusion.