Table II.

Characteristics of the peptides that were differentially expressed peptides between PE and normal pregnancies.

Sequence	Protein ID	Fragment	Protein names	Cellular component	Function	Fold change	P-value
Peptides downregulated in amniotic fluid of pregnancy with PE
KEDEKAPQLMASY	L8E9Q3	61–85	Alternative protein	Unknown	Unknown	−∞	7.48×10−05
DLYLCQWNIIGW			CNKSR2
AAWGQTVLLLHAL	K7EMA2	29–53	Beclin-1	Nucleus	Autophagy	0.5585	1.38×10−02
ANKMGLKFQRMD
CGIADFLSTYQTKVDKDLQSLEDIL	C9JEU5	49–73	Fibrinogen gamma chain	Fibrinogen complex	Platelet activation; protein polymerization; signal transduction	0.5711	4.19×10−02
CLGKACG	E7EN65	704–710	Elastin	Extracelluar region	Extracellular	0.6332	4.42×10−03
IDHYCKHSEEIKDNCRNWKPTCDVF	G3V493	33–57	Protein SIX6OS1	unknown	Unknown	0.7276	2.44×10−02
FMLKPGDLLYFPRGTIHQADTPAGL	H0Y9L8	70–94	Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA	Cytoplasm; nucleus	Unknown	0.7587	8.28×10−03
Peptides upregulated in amniotic fluid of pregnancy with PE
VDGKCCKECKCEH NFYDEYFLWKNK	H0YIT4	95–119	Protein kinase C-binding protein NELL2	Unknown	Unknown	1.1962	4.96×10−02
CEKIGKIYEMRMM MDFNGNNRGYAF	Q7Z2U9	76–100	A1CF protein	Nucleus	Nucleic acid binding; nucleotide binding	1.2911	4.31×10−02
EEKAGKESDEKEQEQDKDRELQQAE	F8VU11	824–848	Pre-mRNA-processing factor 40 homolog B	Unknown	Unknown	1.2913	2.49×10−02
IKITWFANDREIKESSKHRMSFVES	Q8WZ42	5256–5280	Titin	Cytoplasm; nucleus	Kinase, Transferase, Serine/threonine-protein kinase	1.3004	1.12×10−02
QELEKTLEESKEMDIKRKENKGNDT	Q7Z6Z7	1698–1722	E3 ubiquitin-protein ligase HUWE1	Cytoplasm; nucleus	protein ubiquitination	1.3191	1.19×10−02
DEAWKSFLENPLTAATKAMMSINGD	F8WFB0	30–54	Grainyhead-like protein 1 homolog	Unknown	Unknown	1.3407	3.43×10−02
RSRESRLPQSVRHH LIISHFSSKDF	Q9UK30	26–50	Ras-GRF2	Unknown	Unknown	1.3864	4.47×10−02
MDENFISRAFATMGETVMSVKIIRN	B7Z6E0	14–38	cDNA FLJ52201, mRNA	Nucleus	Nucleic acid binding; nucleotide binding	1.4922	1.01×10−02
PSISAAQNALKKQINSVNKFKLRTS	Q15032	1060–1084	R3H domain-containing protein 1	Nucleus	Poly(A) RNA binding	1.4973	2.78×10−03
QGEDKAKLMRAYMQEPLFVEFADCC	Q59GB6	93–117	Thyroid hormone receptor interactor	Membrane	Receptor	1.5141	2.93×10−02
ASNPSLQEKKESSSALTESSGHLDH	O94854	24–48	Uncharacterized protein KIAA0754	Membrane	Unknown	1.5746	3.18×10−02
SENELLELFEKMMEDMNLNEDKKAP	C9JDG0	118–142	Deleted	Unknown	Unknown	1.6752	1.22×10−02
AAQSEGGPKSRDSKRPVATRGAKEH	Q08ET8	18–42	WRAP53	Unknown	Unknown	1.7077	1.75×10−03
TESETKAFMAVCIETAKRYNLDDYR	Q5T4S7	4302–4326	E3 ubiquitin-protein ligase UBR4	Membrane; cytoplasm; nucleus	Ligase activity; ubiquitin-protein transferase activity; zinc ion binding	1.7425	1.38×10−02
NWKEEEKKKYYDAKTEDKVRVMADS	O75601	36–60	Mih1/Tx protein	Nucleus	Regulation of apoptotic process	3.1777	3.19×10−02
QSLWEKACENQRNLNMETARISHWK	I1YAQ4	51–75	LOC340970	Intracellular	Zinc ion binding	4.5037	2.83×10−02
RKKQKIIKMLLIVALLFILSWLPLW	Q9Y5X5	369–393	Neuropeptide FF receptor 2	Membrane	G-protein coupled receptor, receptor, transducer	+∞	7.76×10−04

PE, preeclampsia.