Table II.
Functional annotation of differentially-expressed genes via GO enrichment.
| GO identifier | Description | Corrected P-value | Gene count |
|---|---|---|---|
| Upregulated genes | |||
| 50896 | Response to stimulus | 3.55E-35 | 133 |
| 5623 | Cell | 3.29E-29 | 345 |
| 5488 | Binding | 6.81E-27 | 277 |
| 5515 | Protein binding | 1.23E-24 | 180 |
| 9987 | Cellular process | 2.79E-22 | 242 |
| 16020 | Membrane | 1.11E-20 | 210 |
| 50789 | Regulation of biological process | 5.12E-20 | 195 |
| 5615 | Extracellular space | 9.41E-19 | 46 |
| 5737 | Cytoplasm | 1.07E-17 | 190 |
| 5622 | Intracellular | 6.92E-14 | 233 |
| 3824 | Catalytic activity | 1.02E-12 | 139 |
| 51704 | Multi-organism process | 2.10E-12 | 30 |
| 5576 | Extracellular region | 1.27E-11 | 66 |
| 8219 | Cell death | 1.42E-09 | 31 |
| 8152 | Metabolic process | 1.69E-09 | 159 |
| 7610 | Behavior | 7.73E-09 | 28 |
| 7275 | Multicellular organismal development | 8.00E-08 | 79 |
| 6810 | Transport | 1.65E-07 | 71 |
| 9986 | Cell surface | 5.58E-07 | 20 |
| 30234 | Enzyme regulator activity | 1.98E-06 | 29 |
| 16787 | Hydrolase activity | 2.57E-06 | 62 |
| 9056 | Catabolic process | 8.94E-06 | 32 |
| 6928 | Cellular component movement | 1.30E-04 | 18 |
| 30154 | Cell differentiation | 1.47E-04 | 48 |
| 46903 | Secretion | 1.49E-04 | 14 |
| 16740 | Transferase activity | 1.96E-04 | 46 |
| 16209 | Antioxidant activity | 6.51E-04 | 5 |
| 32501 | Multicellular organismal process | 2.61E-03 | 96 |
| 16301 | Kinase activity | 2.78E-03 | 24 |
| 16491 | Oxidoreductase activity | 4.81E-03 | 21 |
| 4871 | Signal transducer activity | 8.77E-03 | 61 |
| 5578 | Proteinaceous extracellular matrix | 2.39E-02 | 10 |
| 4872 | Receptor activity | 3.77E-02 | 53 |
| 7154 | Cell communication | 4.28E-02 | 15 |
| Downregulated genes | |||
| 5623 | Cell | 3.0026E-32 | 328 |
| 5488 | Binding | 6.1503E-31 | 268 |
| 5515 | Protein binding | 7.6309E-31 | 182 |
| 50789 | Regulation of biological process | 9.9221E-20 | 183 |
| 16020 | Membrane | 2.2576E-19 | 194 |
| 9987 | Cellular process | 3.2737E-19 | 219 |
| 5737 | Cytoplasm | 7.2487E-15 | 171 |
| 50896 | Response to stimulus | 1.2201E-13 | 87 |
| 5622 | Intracellular | 2.213E-13 | 216 |
| 7275 | Multicellular organismal development | 2.9385E-11 | 84 |
| 8152 | Metabolic process | 2.0536E-10 | 152 |
| 30154 | Cell differentiation | 2.1508E-10 | 61 |
| 5576 | Extracellular region | 4.247E-09 | 57 |
| 30234 | Enzyme regulator activity | 1.0124E-08 | 32 |
| 5615 | Extracellular space | 2.4893E-08 | 29 |
| 3824 | Catalytic activity | 6.7488E-08 | 115 |
| 6810 | Transport | 1.433E-07 | 67 |
| 9986 | Cell surface | 1.4591E-07 | 20 |
| 32501 | Multicellular organismal process | 1.8029E-07 | 108 |
| 7610 | Behavior | 4.5276E-06 | 22 |
| 43170 | Macromolecule metabolic process | 0.00004114 | 96 |
| 15075 | Ion transmembrane transporter activity | 4.7081E-05 | 24 |
| 16787 | Hydrolase activity | 4.9943E-05 | 54 |
| 7154 | Cell communication | 0.00010978 | 21 |
| 30528 | Transcription regulator activity | 0.00013308 | 33 |
| 5215 | Transporter activity | 0.00026927 | 30 |
| 8219 | Cell death | 0.00052849 | 19 |
| 9058 | Biosynthetic process | 0.00075689 | 62 |
| 5634 | Nucleus | 0.0020871 | 83 |
| 16740 | Transferase activity | 0.0025576 | 39 |
| 6519 | Cellular amino acid and derivative metabolic process | 0.00291 | 12 |
| 16301 | Kinase activity | 0.0081283 | 21 |
| 9056 | Catabolic process | 0.0081283 | 22 |
| 6139 | Nucleobase | 0.010583 | 55 |
| 5578 | Proteinaceous extracellular matrix | 0.012461 | 10 |
| 43062 | Extracellular structure organization | 0.013556 | 7 |
| 4871 | Signal transducer activity | 0.01531 | 55 |
| 6928 | Cellular component movement | 0.017115 | 12 |
| 4872 | Receptor activity | 0.034186 | 49 |
| 16874 | Ligase activity | 0.046244 | 10 |
GO, Gene Ontology.