Table I.
Gene ontology analysis of DEGs.
| Expression | Category | GO-ID | Term | Gene count | % | P-value |
|---|---|---|---|---|---|---|
| Upregulated | BP | GO:0055085 | Transmembrane transport | 43 | 12.6 | 5.10×10−6 |
| BP | GO:0006811 | Ion transport | 45 | 13.2 | 1.40×10−5 | |
| BP | GO:0051209 | Release of sequestered calcium ion into cytosol | 10 | 2.9 | 3.20×10−5 | |
| BP | GO:0051283 | Negative regulation of sequestering of calcium ion | 10 | 2.9 | 3.20×10−5 | |
| BP | GO:0097553 | Calcium ion transmembrane import into cytosol | 10 | 2.9 | 3.50×10−5 | |
| MF | GO:0042625 | ATPase coupled ion transmembrane transporter activity | 7 | 2.0 | 1.10×10−3 | |
| MF | GO:0019829 | Cation-transporting ATPase activity | 6 | 1.8 | 2.90×10−3 | |
| MF | GO:0022853 | Active ion transmembrane transporter activity | 7 | 2.0 | 6.10×10−3 | |
| MF | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances | 7 | 2.0 | 7.20×10−3 | |
| MF | GO:0070330 | Aromatase activity | 4 | 1.2 | 7.50×10−3 | |
| CC | GO:0045202 | Synapse | 30 | 8.8 | 5.30×10−6 | |
| CC | GO:0005887 | Integral component of plasma membrane | 46 | 13.5 | 5.10X10−5 | |
| CC | GO:0031226 | Intrinsic component of plasma membrane | 46 | 13.5 | 1.30×10−4 | |
| CC | GO:0098794 | Postsynapse | 17 | 5.0 | 1.50×10−4 | |
| CC | GO:0044456 | Synapse part | 23 | 6.7 | 1.50×10−4 | |
| Downregulated | BP | GO:0007166 | Cell surface receptor signaling pathway | 226 | 17.2 | 2.00×10−9 |
| BP | GO:0030029 | Actin filament-based process | 79 | 6.0 | 4.30×10−9 | |
| BP | GO:0006928 | Movement of cell or subcellular component | 165 | 12.5 | 4.30×10−9 | |
| BP | GO:2000145 | Regulation of cell motility | 85 | 6.5 | 1.10×10−8 | |
| BP | GO:0040012 | Regulation of locomotion | 87 | 6.6 | 1.70×10−8 | |
| MF | GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 34 | 2.6 | 1.10×10−6 | |
| MF | GO:0005085 | Guanyl-nucleotide exchange factor activity | 41 | 3.1 | 1.30×10−6 | |
| MF | GO:0019838 | Growth factor binding | 23 | 1.7 | 4.00×10−6 | |
| MF | GO:0005102 | Receptor binding | 126 | 9.6 | 4.90×10−6 | |
| MF | GO:0004713 | Protein tyrosine kinase activity | 26 | 2.0 | 4.20×10−5 | |
| CC | GO:0005578 | Proteinaceous extracellular matrix | 55 | 4.2 | 3.90×10−10 | |
| CC | GO:0031012 | Extracellular matrix | 67 | 5.1 | 1.10×10−8 | |
| CC | GO:0098590 | Plasma membrane region | 101 | 7.7 | 1.20×10−8 | |
| CC | GO:0044421 | Extracellular region part | 295 | 22.4 | 2.00×10−7 | |
| CC | GO:0005576 | Extracellular region | 333 | 25.3 | 4.00×10−6 |
DEGs, differentially expressed genes; BP, biological process; MF, molecular function; CC, cellular component.