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. 2018 Feb 1;17(4):4899–4908. doi: 10.3892/mmr.2018.8535

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Therapeutic effects of AbMTA2 on A549-bearing mice in vivo. (A) Growth of non-small cell lung carcinoma tumor in A549-bearing mice following treatment with the indicated agents. (B) ERK and AKT expression levels in the experimental tumor on day 25. Magnification, ×400. (C) VEGF and EGF expression levels in the experimental tumor on day 25. Magnification, ×400. (D) Long-term (120-day observation) survival of A549-bearing mice following treatment with the indicated agents. The data are presented as the mean ± standard error of the mean of three independent experiments. **P<0.01 vs. control. Ab, antibody; MTA2, metastasis associated protein MTA2; ERK, extracellular signal-regulated kinase; AKT, RAC-α serine/threonine protein kinase; VEGF, vascular endothelial growth factor; EGF, pro-epidermal growth factor; si, small interfering.