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Immunohistochemical staining for COX-2 in rat hippocampi (magnification, ×200). (A) Control group COX-2 was not expressed or expressed at a very low level. (B) Post-traumatic stress disorder group COX-2 expression was visibly enhanced and mainly localized to the cytoplasm and membranes of keratinocytes in rat hippocampi. (C) Intervention group COX-2 level was decreased following treatment with COX-2 inhibitor. COX-2, cyclooxygenase-2.
