Table VI.
Top pathways involved by number of genes targeted by dysregulated miRNAs, including miR-122, miR-135a and let-7c, obtained from maternal plasma samples.
| Pathway | Nominal P-value | Matched entities | Pathway entities |
|---|---|---|---|
| Hs calcium regulation in the cardiac cell WP536-75219a | 0.00002112 | 2 | 150 |
| Hs MAPK cascade WP422 −72129a | 0.00002112 | 2 | 29 |
| Hs inflammatory response pathway WP453-63217 | 0.00002112 | 2 | 33 |
| Hs focal adhesion WP306-71714a | 0.00002112 | 2 | 188 |
| Hs myometrial relaxation and contraction pathways WP289-72107a | 0.004421 | 4 | 156 |
| Hs GPCRs, Class C Metabotropic glutamate, pheromone WP501-63205 | 0.004632 | 1 | 15 |
| Hs Regulation of toll like receptor signaling pathway WP1449-72114 | 0.004632 | 1 | 150 |
| Hs Toll-like receptor signaling pathway WP75-72133 | 0.004632 | 1 | 102 |
| Hs IL-1 signaling pathway WP195-74010 | 0.004632 | 1 | 55 |
| Hs Wnt signaling pathway and pluripotency WP399-74897a | 0.004632 | 1 | 100 |
| Hs JAK STAT WP2593-74127a | 0.004632 | 1 | 44 |
| Hs MAPK signaling pathway WP382-72103a | 0.009645 | 3 | 168 |
| Hs Apoptosis Modulation and Signaling WP1772-63162 | 0.009645 | 3 | 93 |
| Hs apoptosis WP254-72110a | 0.009645 | 3 | 84 |
| Hs GPCRs, class A rhodopsin-like WP455-74420a | 0.009645 | 3 | 261 |
a
Pathways are common pathway in villous sample and maternal plasma sample obtained from pathway analysis. Matched entities, genes targeted by dysregulated miRNA; Pathway entities, total number of genes in the pathway.