Figure 2.

Effect of MRS on the Aβ (1–42)-induced production of IL-1β and TNF-α. The BV-2 cells were pretreated with different concentrations of MRS for 2 h, followed by co-treatment with 5 µM Aβ (1–42) for another 12 h. The culture supernatants were collected and assayed for (A) IL-1β and (B) TNF-α. Each value indicates the mean ± standard deviation from three independent experiments. ^#P<0.01, vs. untreated control cells. *P<0.05, vs. cells treated with Aβ (1–42) alone. MRS, medicated rat serum containing Gengnianchun formula; Aβ, amyloid β; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-α.