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. 2018 Jan 25;17(4):5247–5257. doi: 10.3892/mmr.2018.8480

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Molecular functions of the overlapping proteins, and the correlation between the metabolites regulated in BYF-treated rats and target proteins. The molecular functions of the overlapping proteins were analyzed using BiNGO. The area of a node was proportional to the number of proteins in the test set. (A) Molecular function of overlapping proteins between the potential targets and transcript measurements in lung tissues of BYF-treated rats. (B) Molecular function of overlapping proteins between the potential targets and proteome measurements in lung tissues of BYF-treated rats. Red indicates the predominant functions of the proteins, and the molecular functions associated with BYF-therapeutic effect. (C) Metscape software was used to build a compound reaction network: Metabolites (hexagons) and metabolic enzymes (circles) are presented as nodes and reactions are presented as edges. Inputted metabolites are shown in blue, inputted target proteins are shown in red. BYF, Bufei Yishen formula.