Table II.
Top 5 enriched Kyoto Encyclopedia of Genes and Genomes terms obtained from the subnet module analysis.
| Term | Count | P-value | Proteins |
|---|---|---|---|
| Cluster 1 | |||
| Chemokine signaling pathway | 10 | 3.14×10−13 | CCR7, GNAI1, CXCR4, CCL21, CXCL2 … |
| Cytokine-cytokine receptor interaction | 7 | 5.07×10−7 | CCR7, CXCR4, CCL21, CXCL9, CCL19 … |
| Rheumatoid arthritis | 3 | 0.007870 | CXCL6, CCL5, CXCL12. |
| NF-κB signaling pathway | 3 | 0.008048 | CCL21, CCL19, CXCL12. |
| Leukocyte transendothelial migration | 3 | 0.014455 | GNAI1, CXCR4, CXCL12. |
| Cluster 2 | |||
| Complement and coagulation cascades | 3 | 5.85×10−4 | A2M, SERPINE1, PLG. |
| p53 signaling pathway | 2 | 0.037772 | SERPINE1, IGF1. |
| Cluster 3 | |||
| Retinol metabolism | 7 | 5.57×10−13 | CYP3A4, CYP4A11, CYP2B6, UGT2B11, CYP26A1 … |
| Steroid hormone biosynthesis | 4 | 1.11×10−5 | CYP3A4, UGT2B11, CYP1A2, UGT2B7. |
| Chemical carcinogenesis | 4 | 2.94×10−5 | CYP3A4, UGT2B11, CYP1A2, UGT2B7. |
| Metabolic pathways | 7 | 3.00×10−5 | CYP3A4, CYP4A11, CYP2B6, UGT2B11, CYP26A1 … |
| Drug metabolism cytochrome P450 | 3 | 7.30×10−4 | CYP3A4, CYP2B6, CYP1A2. |
| Cluster 4 | |||
| Chemical carcinogenesis | 9 | 2.31×10−16 | GSTA2, CYP3A7, CYP2C19, CYP2C9, CYP2C18 … |
| Drug metabolism-cytochrome P450 | 6 | 8.13×10−10 | GSTA2, CYP2C19, CYP2C9, CYP2C8, CYP2A6 … |
| Metabolism of xenobiotics by | 5 | 2.30×10−7 | GSTA2, CYP2C9, EPHX1, CYP2A6, CYP2E1. |
| cytochrome P450 | |||
| Retinol metabolism | 5 | 4.91×10−7 | CYP3A7, CYP2C9, CYP2C18, CYP2C8, CYP2A6. |
| Linoleic acid metabolism | 4 | 3.70×10−6 | CYP2C19, CYP2C9, CYP2C8, CYP2E1. |