Figure 6.

MDA7/IL24 overexpression leads to changes in gene expression profile of SMMC-7721 cells. (A) Gene expression profiling results. Heatmap represents 43 genes shown to be differentially expressed between SMMC-7721 cells infected with negative-control (NC) lentivirus or LV-MDA7/IL24 (OE). Genes and samples are listed in rows and columns, respectively. Color scale: red represents gene expression upregulation; green, downregulation of gene expression. (B) Schematic representation of a network including MDA7/IL24 and genes involved in cell cycle regulation and apoptosis. Solid arrows, confirmed regulatory relationships; dotted lines, predicted regulatory relationships; T bars, inhibitory relationships.