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. 2018 Feb 15;17(4):5805–5813. doi: 10.3892/mmr.2018.8609

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — PBX3 knockdown inhibits the cytokine activity and confers protective effects during sepsis. (A) TNF-α and (B) IL-6 levels were measured in RAW264.7 cells with HMGB1 addition alone or plus Lenti-PBX3-shRNA infection. Effects of PBX3 siRNA injection intravenously on (C) HMGB1-induced (2 µg/mouse, intravenously) or (D) CLP-induced (at 24 h after CLP) IL-6 secretion in mice was examined using ELISA (expressed µg/mouse, n=6). Values were expressed as the mean + standard deviation (n=3). **P<0.01 vs. Control or as indicated. PBX3, pre-B cell leukemia transcription factor 3; HMGB1, high mobility group box 1; LPS, lipopolysaccharide; shRNA, short hairpin RNA; IL, interleukin; CLP, cecal ligation and puncture.