Table II.
Differentially expressed known coat color genes in black vs. white sheep skin.
| Symbol | Gene name | Differential expression | Function |
|---|---|---|---|
| Edn3 | Endothelin 3 | 4.903 | Growth and differentiation factor |
| Dct (Trp-2) | Dopachrome tautomerase | 6.023 | Melanosomal enzyme |
| Gpnmb | Glycoprotein NMB | 4.281 | Apparent melanosomal component |
| Matp | Membrane-associated transporter protein | 32.75 | Apparent transporter |
| Rab38 | RAB38, member RAS oncogene family | 2.206 | Targeting of Trp1 |
| Si | Silver | 25.2 | Melanosome matrix |
| Tyr | TYR | 61.79 | Melanosomal enzyme |
| Trp-1 | TYR-related protein 1 | 284.17 | Melanosomal protein |
| Mlph | Melanophilin | 27.75 | Melanosome transport |
| Ggt1 | Glutamyltranspeptidase 1 | 5.747 | Glutathione metabolism (pheomelanin synthesis) |
| Mc1r | Melanocortin 1 receptor | 9.315 | Eumelanin/pheomelanin switch (among others) |
| Mgrn1 | Mahogunin, ring finger 1 | 2.814 | Melanin color, CNS role. E3 ubiquitin ligase |