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. 2018 Feb 8;17(4):5894–5902. doi: 10.3892/mmr.2018.8583

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Copyright: © Nie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Effects of exogenous polyunsaturated fatty acids (PUFAs) on mammalian target of rapamycin complex 1 (mTORC1) and autophagy. (A) AA activated mTORC1 independently (lane 1 vs. lane 3), while docosahexaenoic acid (DHA) ameliorated amino acid- and arachidonic acid (AA)-induced activation of the mTORC1 signaling pathway (lane 2 vs. lane 4; lane 3 vs. lane 5). (B) Under amino acid starvation, AA and DHA inhibited and enhanced expression of the autophagic marker LC3-II protein, respectively; the effect on LC3I was opposite to that of LC3-II and the effect on P62 was the same as LC3-II. (C) DHA independently inhibited mTORC1.