Table 2. Sex-stratified association analyses between the Genetic Risk Score (GRS) and time to the first cardiovascular event using a Cox proportional-hazards model from age at baseline^a for a total of 22,568 cardiovascular diseases (CVD) free individuals at baseline.

Coronary Heart Disease Death, N events=1,056
	Women			Men
Study	HRc	95% CI	p	HRc	95%CI	p
FHS	1.29	1.08-1.54	0.005	0.90	0.73-1.12	0.36
ARIC	1.14	0.89-1.45	0.29	1.23	1.01-1.50	0.04
RSI	1.04	0.91-1.18	0.58	1.00	0.86-1.16	0.99
RSII	1.13	0.55-2.32	0.73	1.57	0.77-3.21	0.21
Meta-Analysis	1.12	1.02-1.24	0.03	1.05	0.94-1.16	0.34
Composite Endpointb, N events=4,970
Study	HRc	95% CI	p	HRc	95%CI	p
FHS	1.22	1.08-1.37	0.001	0.91	0.80-1.05	0.19
ARIC	1.06	0.93-1.22	0.36	1.00	0.94-1.07	0.91
RSI	1.06	0.99-1.14	0.11	0.99	0.91-1.07	0.76
RSII	1.27	0.95-1.69	0.11	1.08	0.81-1.45	0.60
Meta-Analysis	1.10	1.04-1.16	9.7×10-4	0.99	0.95-1.04	0.71

^aAnalyses were adjusted for sex, age at entry point, principal components, familial relatedness, study center and known cardiovascular factors (current smoking, body mass index, hypertension, type 2 diabetes, total cholesterol and lipid treatment). The Hazard Ratios (HRs) are presented per 1 unit increase in GRS. A 1-unit increase in GRS corresponds to a 1-year decrease in expected age at natural menopause.

^ba composite end point of cardiovascular disease events defined as myocardial infarction, stroke, congestive heart failure and death from coronary heart disease

^cHazard Ratio