Table 1.
Characteristics of Persons in the Training and Testing Datasets
| Total | Training | Testing | p-value* | ||||
|---|---|---|---|---|---|---|---|
| No. or Mean | % or SD | No. or Mean | % or SD | No. or Mean | % or SD | ||
| No. of participants † | 571 | 100% | 286 | 50% | 285 | 50% | |
| Trial | 0.71 | ||||||
| CIGTS | 266 | 100% | 131 | 49% | 135 | 51% | |
| AGIS | 305 | 100% | 155 | 51% | 150 | 49% | |
| Sex | 0.87 | ||||||
| Male | 272 | 48% | 135 | 47% | 137 | 48% | |
| Female | 299 | 52% | 151 | 53% | 148 | 52% | |
| Race | 0.26 | ||||||
| Black | 288 | 50% | 154 | 54% | 134 | 47% | |
| White | 263 | 46% | 123 | 43% | 140 | 49% | |
| Other | 20 | 4% | 9 | 3% | 11 | 4% | |
| Mean (SD) no. of visits per patient‡ | 11.2 | 5.1 | 11.0 | 5.0 | 11.3 | 5.3 | 0.49 |
| Mean (SD) of age [years] | 64.2 | 10.9 | 64.2 | 10.9 | 64.3 | 11.0 | 0.91 |
| Mean (SD) of baseline MD [dB] | −7.49 | 5.39 | −7.39 | 5.53 | −7.59 | 5.26 | 0.66 |
| Mean (SD) of baseline PSD [dB] | 6.42 | 3.69 | 6.45 | 3.68 | 6.39 | 3.70 | 0.85 |
| Mean (SD) of baseline IOP [mmHg] | 17.62 | 3.60 | 17.63 | 3.35 | 17.62 | 3.83 | 0.97 |
| Progressor Status § | 0.71 | ||||||
| Fast | 121 | 21% | 58 | 20% | 63 | 22% | |
| Slow | 267 | 47% | 132 | 46% | 135 | 47% | |
| Non | 183 | 32% | 96 | 34% | 87 | 31% | |
IOP = intraocular pressure; MD = mean deviation; PSD = pattern standard deviation; SD = standard deviation; AGIS = Advanced Glaucoma Intervention Study; CIGTS = Collaborative Initial Glaucoma Treatment Study; mmHg = millimeter of mercury; dB = decibels.
Fisher Exact Test and Student’s t-test were used for categorical and continuous variables, respectively.
All participants contributed only one eye.
Each visit includes tonometry and perimetric testing.
Designation of progression status for each patient was made based on all MD readings for that patient using the criteria described in the Methods section. Further, the fast-, slow-, and non-progressor patient sets are mutually exclusive subsets of the whole data set.