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. Author manuscript; available in PMC: 2018 Aug 24.
Published in final edited form as: Obesity (Silver Spring). 2018 Feb 24;26(4):683–688. doi: 10.1002/oby.22129

Figure 3. Effect of moderate (5%) weight loss on plasma lactate concentration ([LAC]) during postabsorptive conditions and a hyperinsulinemic-euglycemic clamp procedure.

Figure 3

(A) Fasting [LAC] before and after weight maintenance and 5% weight loss. *Value significantly different from corresponding weight maintenance value, interaction p=0.009 evaluated by using two-way repeated measures ANOVA. (B) Change in [LAC] induced by a hyperinsulinemic-euglycemic clamp procedure before and after weight maintenance and 5% weight loss. **Value different from corresponding weight maintenance value, interaction p=0.06 evaluated by using one-way repeated measures ANOVA. (C) Relationship between the relative change in fasting [LAC]pl with the relative change in glucose rate of appearance (Ra). (D) Relationship between the relative change in fasting [LAC] with the relative change in insulin sensitivity [assessed as the percent increase in glucose rate of disappearance during a hyperinsulinemic-euglycemic clamp procedure].