Urinary function (A), bowel habits (B), and sexual function (C) are shown as quantitated by the EPIC questionnaire over the four years following very cold minimum tumor temperature cryotherapy (blue line), moderate-cold minimum tumor temperature cryotherapy (red line), or AS (black line). Asterisks indicate statistically significant differences relative to AS. *p<0.05, **p<0.01, ***p<0.001.