Table 1.
Characteristics of patients who underwent Cryotherapy or Active Surveillance as Primary Management for Prostate Cancer
| Cryotherapy (n=129) | AS (n=68) | Total patients (n=197) | p-value1 | |
|---|---|---|---|---|
| Survey packets (EPIC/IIEF) analyzed | 335 | 212 | 547 | |
| Median age | 69 | 66 | 68 | 0.007 |
| Focal | 68 | 0.00022 | ||
| Total | 74 | |||
| Very cold minimum tumor temperature | 70 | 0.663 | ||
| Moderate-cold minimum tumor temperature | 69 | |||
| Race or ethnic group - no. (%) | 0.0074 | |||
| White | 99/122 (81.1) | 63/66 (95.5) | 162/188 (86.0) | |
| Black | 15/122 (12.3) | 3/66 (4.5) | 18/188 (9.6) | |
| Hispanic | 5/122 (3.6) | 0/66 (0) | 5/188 (2.7) | |
| Asian | 1/122 (0.8) | 0/66 (0) | 1/188 (0.5) | |
| Other | 2/122 (1.6) | 0/66 (0) | 2/188 (1.0) | |
| Cryotherapy type – no. (%) | ||||
| Focal | 89/127 (70) | |||
| Total | 38/127 (30) | |||
| Very cold minimum tumor temperature | 52/116 (55) | |||
| Moderate-cold minimum tumor temperature | 64/116 (45) | |||
| Median PSA at treatment or initiation of AHS overall Gleason score | 6.1 | 5.0 | 5.7 | 0.08 |
| Median overall (%) | 7 | 6 | 6 | N/A5 |
| 0–6 | 48/128 (37.5) | 53/64 (82.8) | 101/192 (52.6) | |
| 7 (3+4, 4+3) | 55/128 (43.0) | 11/64 (17.2) | 66/192 (34.3) | |
| 8+ | 25/128 (19.5) | 0/64 (0) | 25/192 (13.0) | |
| Focal | 0.0542 | |||
| 0–6 | 37 | |||
| 7 (3+4, 4+3) | 39 | |||
| 8+ | 12 | |||
| Total | ||||
| 0–6 | 11 | |||
| 7 (3+4, 4+3) | 15 | |||
| 8+ | 12 | |||
| Very cold minimum tumor temperature | 0.133 | |||
| 0–6 | 23 | |||
| 7 (3+4, 4+3) | 23 | |||
| 8+ | 6 | |||
| Moderate-cold minimum tumor temperature | ||||
| 0–6 | 20 | |||
| 7 (3+4, 4+3) | 28 | |||
| 8+ | 16 | |||
| Prostate volume median (g) | 41 | 39 | 41 | 0.60 |
| Alpha-blocker / 5-alpha-reductase inhibitor use | ||||
| Focal | 48 | 0.562 | ||
| Total | 23 | |||
| Very cold minimum tumor temperature | 32 | 0.413 | ||
| Moderate-cold minimum tumor temperature | 33 | |||
| PDE5 inhibitor use | ||||
| Focal | 42 | 0.242 | ||
| Total | 14 | |||
| Very cold minimum tumor temperature | 25 | 0.553 | ||
| Moderate-cold minimum tumor temperature | 26 | |||
1
p-values were obtained for mean differences between cryotherapy and AS groups, unless otherwise noted
2
Comparison between focal and total cryotherapy group
3
Comparison between cryotherapy very cold minimum tumor temperature and moderate-cold minimum tumor temperature groups
4
Comparison of white versus black and other races/ethnicities combined
5
N/A, not applicable; p-value was not obtained due to the lack of AS patients with Gleason scores greater than or equal to 8.