Table 2.

Weighted distributions of SG-corrected urinary phenols and parabens and thyroid hormones by study visit of sample collection in pregnancy (N = 439 subjects). Median gestational weeks: Visit 1: 10, Visit 2: 18, Visit 3: 26, Visit 4: 35.

		All	Visit 1	Visit 2	Visit 3	Visit 4
	% LOD (LOD)	GM (GSD)	GM (GSD)	GM (GSD)	GM (GSD)	GM (GSD)
Urinary Biomarkers (μg/L)
2,4-DCP	15.7 (0.2)	0.89 (3.51)	0.95 (3.85)	0.93 (3.50)*	0.81 (3.52)*	0.88 (3.14)*
2,5-DCP	3.1 (0.2)	5.11 (6.42)	5.35 (7.08)	5.63 (6.63)	4.69 (6.46)*	4.77 (5.47)*
BP-3	0.1 (0.4)	55.82 (8.48)	52.62 (8.16)	61.66 (8.11)	51.62 (8.76)	57.94 (9.02)
BPB	29.3 (0.2)	1.19 (7.14)	1.21 (7.53)	1.29 (6.71)	1.18 (7.39)	1.09 (6.96)
EPB	38.1 (1)	3.56 (5.82)	3.73 (6.20)	3.92 (6.05)	3.45 (5.67)*	3.15 (5.33)*
MPB	0.1 (1)	169.64 (4.31)	152.43 (4.14)	208.05 (4.07)	161.80 (4.55)	161.49 (4.45)
PPB	1 (0.2)	37.35 (5.71)	33.90 (5.67)	50.85 (5.04)*	34.36 (5.82)	32.63 (6.23)
TCS	17.4 (2)	16.63 (6.65)	16.82 (6.98)	17.44 (6.20)	14.91 (6.49)	17.35 (6.95)
TCB	85.9 (2)	<LOD	<LOD	<LOD	<LOD	<LOD
BPS	73.8 (0.4)	<LOD	<LOD	<LOD	<LOD	<LOD
Thyroid Hormones
FT4 (ng/dL)	98.2 (0.1)	1.10 (1.52)	1.37 (1.48)	1.08 (1.49)*	0.99 (1.50)*	0.96 (1.45)*
TSH (μIU/mL)	99.5 (0.01)	1.13 (2.12)	0.77 (2.75)	1.29 (1.92)*	1.27 (1.68)*	1.31 (1.71)*
T3 (ng/mL)	100 (0.1)	1.56 (1.30)	1.35 (1.31)	1.61 (1.27)*	1.65 (1.27)*	1.66 (1.29)*
T4 (μg/dL)	100 (0.3)	10.22 (1.21)	9.98 (1.22)	10.61 (1.18)*	10.29 (1.20)*	10.01 (1.23)
T3/T4 ratio	-	0.15 (1.27)	0.14 (1.21)	0.15 (1.24)*	0.16 (1.27)*	0.17 (1.29)*

GM: Geometric mean

GSD: Geometric standard deviation

^*Significant difference (p<0.05) in urinary biomarker metabolite or thyroid hormone compared to reference (visit 1) using linear mixed models with a random intercept