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. 2018 Feb 15;4(1):1–12. doi: 10.1007/s40778-018-0110-3

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Cellular architecture of the hematopoietic stem cell (HSC) niche in the adult bone marrow. The osteoblastic niche resides along the endosteum, located at the periphery of the bone, while the vascular niche is centrally localized in the bone marrow. HSC are localized adjacent to sinusoids and arterioles. The central vascular niche is thought to favor activation and differentiation of HSC. Cx43-comprised gap junctions between osteoblasts regulate HSC behavior within the niche. Although vascular endothelial cells and HSC express Cx43, the existence, and physiologic role, of Cx43-mediated interactions between vascular endothelial cells and HSC remains to be determined