Table 2.
Race | SNP | A1 | FRQ | Rsqa | Meta Effect | Meta SE | Meta P Value | Dir | PEAR‐2 Effect | PEAR‐2 SE | PEAR‐2 P Value | Rsqb |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Blackc | rs17117817c | Tc | 0.93c | 1.00 to 0.82c | −5.73c | 1.11c | 2E‐07c | −−c | −5.05c | 1.65c | 2.2E‐03c | 1.00c |
Black | rs10809249 | T | 0.82 | 0.95 to 0.99 | −3.52 | 0.74 | 2E‐06 | −− | −0.57 | 0.98 | 0.56 | 0.99 |
Black | rs12890215 | T | 0.82 | 1.01 to 1.03 | −3.4 | 0.72 | 2E‐06 | −− | −0.48 | 0.92 | 0.602 | 1.00 |
Black | rs1045580 | T | 0.85 | 0.95 to 1.02 | 3.56 | 0.76 | 2E‐06 | ++ | 0.62 | 1.02 | 0.53 | 1.00 |
Black | rs2806495 | A | 0.10 | 0.96 to 0.82 | 4.67 | 0.99 | 2E‐06 | ++ | −0.53 | 1.29 | 0.67 | 1.00 |
Black | rs7738600 | A | 0.51 | 1.05 to 1.03 | −2.6 | 0.56 | 4E‐06 | −− | −0.24 | 0.71 | 0.73 | 1.00 |
Black | rs11757000 | T | 0.77 | 0.99 to 0.91 | −3.05 | 0.67 | 5E‐06 | −− | 0.35 | 0.91 | 0.69 | 1.00 |
Black | rs7042878 | C | 0.09 | 1.05 to 1.10 | 4.31 | 0.95 | 5E‐06 | ++ | 1.65 | 1.35 | 0.22 | 1.00 |
Blackc | rs2364349c | Ac | 0.18c | 0.87 to 0.92c | 3.43c | 0.76c | 7E‐06c | ++c | 3.64c | 1.03c | 4E‐04c | 0.98c |
Black | rs4733278 | T | 0.46 | 0.82 to 0.99 | −2.62 | 0.58 | 7E‐06 | −− | 0.01 | 0.75 | 0.98 | 0.99 |
Black | rs11069252 | T | 0.92 | 0.92 to 1.00 | −4.76 | 1.06 | 7E‐06 | −− | 1.21 | 1.37 | 0.37 | 1.00 |
Black | rs12417208 | A | 0.84 | 0.89 to 0.82 | −3.76 | 0.84 | 8E‐06 | −− | −1.43 | 1.09 | 0.19 | 0.93 |
Black | rs3759422 | T | 0.46 | 0.91 to 1.06 | 2.5 | 0.56 | 8E‐06 | ++ | 0.77 | 0.69 | 0.26 | 1.00 |
Black | rs1018353 | T | 0.9 | 0.95 to 0.85 | −4.29 | 0.96 | 8E‐06 | −− | 0.94 | 1.37 | 0.49 | 1.00 |
Black | rs4554901 | T | 0.07 | 0.93 to 1.03 | 4.85 | 1.09 | 8E‐06 | ++ | −0.09 | 1.41 | 0.94 | 0.99 |
Black | rs10145648 | T | 0.74 | 0.98 to 1.00 | −2.85 | 0.64 | 8E‐06 | −− | −0.34 | 0.77 | 0.65 | 1.00 |
Black | rs10809367 | A | 0.14 | 1.18 to 1.18 | 3.41 | 0.77 | 9E‐06 | ++ | 0.95 | 1.18 | 0.42 | 1.00 |
Black | rs10499 | A | 0.95 | 0.94 to 1.10 | −5.67 | 1.28 | 9E‐06 | −− | −2.01 | 2.00 | 0.31 | 1.00 |
Blackc | rs6455914c | Tc | 0.22c | 0.97 to 0.93c | 3.08c | 0.7c | 1E‐05c | ++c | 1.73c | 0.83c | 0.03c | 0.99c |
Black | rs6470259 | A | 0.80 | 0.94 to 0.88 | −3.2 | 0.72 | 1E‐05 | −− | −0.76 | 1.01 | 0.44 | 0.94 |
White | rs955395 | A | 0.36 | 0.99 to 0.96 | −1.7 | 0.35 | 9E‐07 | −− | 0.21 | 0.59 | 0.69 | 0.99 |
White | rs11727192 | T | 0.21 | 0.94 to 0.97 | −1.92 | 0.42 | 5E‐06 | −− | −0.80 | 0.77 | 0.29 | 1.00 |
White | rs10516175 | A | 0.12 | 1.09 to 1.02 | 2.17 | 0.48 | 6E‐06 | ++ | 0.46 | 0.79 | 0.64 | 0.99 |
White | rs13160161 | A | 0.37 | 1.07 to 0.97 | −1.5 | 0.33 | 7E‐06 | −− | −0.34 | 0.67 | 0.71 | 1.00 |
White | rs11641210 | T | 0.89 | 0.99 to 1.00 | 2.32 | 0.52 | 8E‐06 | ++ | −0.50 | 1.00 | 0.61 | 0.99 |
A1 indicates coded allele; Dir, the direction of effect; FRQ, coded allele frequency; GWAS, genome‐wide association study; HR, heart rate; PEAR, Pharmacogenomic Evaluation of Antihypertensive Responses; POS, position; SNP, single nucleotide polymorphism.
Rsq, r‐squared imputation quality metric in the discovery analysis in which the first number represents the imputation quality for the presented SNP in PEAR monotherapy and the second number represents the imputation quality for the presented SNP in PEAR add‐on therapy.
Rsq, r‐squared imputation quality metric in the replication analysis (PEAR2).
Represent polymorphisms with a P value <0.05 in the replication cohort and the effect of the polymorphism on HR in response to β‐blockers is in the same direction in the discovery (Meta Effect) and replication (PEAR‐2 Effect) analysis. Meta represents meta‐analysis between PEAR β‐blocker mono‐ and add‐on therapy.