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. 2018 Mar 3;7(5):e007837. doi: 10.1161/JAHA.117.007837

Figure 2.

Figure 2

Predicted protein topology of ion channels and the location of variations responsible for SUNDS. A, Cardiac sodium channel comprises a pore‐forming ion‐conducting α‐subunit Nav1.5 and ancillary β‐subunits. B through D, Predicted protein topology of Nav1.8 (SCN10A), Kv11.1 (KCNH2), Kv7.1 (KCNQ1), MinK (KCNE1), MiRP1 (KCNE2), CaV1.2 (CACNA1C), and RyR2. Pathogenicity is determined by ACMG guideline. ACMG indicates American College of Medical Genetics; SUNDS, sudden unexplained nocturnal death syndrome.