. 2018 Mar 3;7(5):e007837. doi: 10.1161/JAHA.117.007837

Table 3.

Yields of Gene Variants in SUNDS Versus EAS in ExAC or gnomAD

Gene	Alleles/Total SUNDS Cases (%)	ExAC		gnomAD
Gene	Alleles/Total SUNDS Cases (%)	Alleles/Total EAS Exomes (%)	P Value^a	Alleles/Total EAS Exomes (%)	P Value
Na⁺ channels
SCN5A	13/167 (7.78)	19/4327 (0.43)	<0.001^b	45/9345 (0.48)	<0.001^b
SCN1B	5/167 (2.99)	63/4327 (1.46)	0.214	144/9345 (1.53)	0.249
SCN3B	1/167 (0.60)	3/4327 (0.07)	0.141	5/9345 (0.05)	0.101
SCN10A	5/105 (4.76)	152/4327 (3.51)	0.696	338/9345 (3.58)	0.736
K⁺ channels
KCNQ1	2/152 (1.32)	5/4327 (0.12)	0.022^b	17/9345 (0.18)	0.037^b
KCNH2	3/152 (1.97)	6/4327 (0.14)	0.003^b	15/9345 (0.16)	0.003^b
KCNE1	1/149 (0.67)	0/4327 (0)	0.034^b	0/9345 (0.00)	0.016^b
KCNE2	1/148 (0.68)	0/4327 (0)	0.034^b	0/9345 (0.00)	0.016^b
KCNJ5	1/44 (2.27)	2/4327 (0.05)	0.031^b	4/9345 (0.04)	0.024^b
Ca²⁺ channels
CACNA1C	2/44 (4.55)	5/4327 (0.12)	0.002^b	17/9345 (0.18)	0.004^b
CACNB2	1/44 (2.27)	0/4327 (0)	0.010^b	2/9345 (0.02)	0.014^b
Connexome
PKP2	2/144 (1.39)	0/4327 (0)	0.001^b	0/9345 (0.00)	<0.001^b
DSP	5/40 (12.50)	84/4327 (1.94)	0.002^b	197/9345 (2.09)	0.002^b
GJA1	2/124 (1.61)	0/4327 (0)	0.001^b	0/9345 (0.00)	<0.001^b
VCL	1/44 (2.72)	2/4327 (0.05)	0.031^b	5/9345 (0.05)	0.028^b
Other genes
LRRC10	3/113 (2.65)	18/4327 (0.42)	0.016^b	31/9345 (0.33)	0.008^b
ABCC9	1/44 (2.27)	10/4327 (0.23)	0.107	27/9345 (0.29)	0.126
ACTN2	2/44 (4.55)	4/4327 (0.09)	0.002^b	12/9345 (0.13)	0.002^b
AKAP9	2/44 (4.55)	89/4327 (2.06)	0.241	195/9345 (2.07)	0.244
ANKRD	1/44 (2.27)	11/4327 (0.25)	0.117	22/9345 (0.23)	0.104
DMPK	1/44 (2.27)	0/4327 (0)	0.01^b	9/9345 (0.10)	0.047^b
EYA4	1/44 (2.27)	0/4327 (0)	0.01^b	0/9345 (0.00)	0.005^b
GATA4	2/44 (4.55)	0/4327 (0)	<0.001^b	0/9345 (0.00)	<0.001^b
JUP	1/44 (2.27)	19/4327 (0.44)	0.187	34/9345 (0.36)	0.155
LDB3	2/44 (4.55)	10/4327 (0.23)	0.007^b	26/9345 (0.28)	0.008^b
LMNA	1/44 (2.27)	0/4327 (0)	0.01^b	3/9345 (0.03)	0.019^b
MYBPC3	3/44 (6.82)	8/4327 (0.18)	<0.001^b	19/9345 (0.20)	<0.001^b
MYH6	3/44 (6.82)	20/4327 (0.46)	0.002^b	50/9345 (0.53)	0.002^b
MYH7	2/44 (4.55)	6/4327 (0.14)	0.003^b	10/9345 (0.11)	0.001^b
NUP155	1/44 (2.27)	1/4327 (0.02)	0.02^b	3/9345 (0.03)	0.019^b
SGCD	1/44 (2.27)	55/4327 (1.27)	0.438	143/9345 (1.52)	0.497
TNNT2	1/44 (2.27)	0/4327 (0)	0.01^b	0/9345 (0.00)	0.005^b
Total	107.11	13.68		14.37

EAS indicates East Asian; MAF, minor allele frequency; SUNDS, sudden unexplained nocturnal death syndrome.

Nonsynonymous and splice site variants with MAF <0.01 in all SUNDS cases were compared with EAS in ExAC or gnomAD by χ² tests using the SPSS 20.0. Continuity‐adjusted χ² test or Fisher exact text are also chosen according to expected frequencies of the cells. A 2‐sided P<0.05 was considered significant.

P<0.05.