Table 2.
Cardiovascular Risk Factors, Inflammatory Markers, and Collagen Biomarkers in Subjects With No HF, With HFpEF, and With HFrEF (N=3187)a
| Variable | No HF (n=2984) | HFpEF (n=107) | HFrEF (n=96) | P Value for Difference | ||
|---|---|---|---|---|---|---|
| No HF vs HFpEF | No HF vs HFrEF | HFpEF vs HFrEF | ||||
| ICTP, μg/mL | 3.38±0.02 | 3.68±0.15 | 3.68±0.16 | 0.05 | 0.06 | 0.99 |
| PIIINP, μg/mL | 5.47±0.03 | 5.89±0.18 | 5.55±0.19 | 0.03 | 0.68 | 0.20 |
| Age, y | 62.2±0.19 | 69.3±1.21 | 67.2±1.27 | <0.0001 | <0.0001 | 0.23 |
| Age, race/ethnicity, and sex adjusted | ||||||
| SBP, mm Hg | 126.5±0.35 | 137.4±2.32 | 129.3±2.42 | <0.0001 | 0.27 | 0.01 |
| DBP, mm Hg | 71.9±0.17 | 74.3±1.13 | 72.6±1.18 | 0.04 | 0.58 | 0.29 |
| Hypertension, % | 45.1 | 67.4 | 53.0 | <0.0001 | 0.17 | 0.07 |
| BP Rx, % | 33.4 | 52.6 | 37.8 | 0.0004 | 0.43 | 0.05 |
| HR, bpm | 62.9±0.17 | 65.9±1.12 | 63.9±1.17 | 0.008 | 0.40 | 0.21 |
| Height, cm | 166.3±0.11 | 167.1±0.75 | 167.4±0.78 | 0.31 | 0.18 | 0.79 |
| BMI, kg/m2 | 28.1±0.09 | 30.6±0.59 | 29.4±0.62 | <0.0001 | 0.04 | 0.17 |
| LDL‐C, mg/dL | 117.5±0.58 | 110.8±3.81 | 118.1±3.94 | 0.08 | 0.88 | 0.18 |
| HDL‐C, mg/dL | 51.1±0.24 | 48.7±1.61 | 49.3±1.68 | 0.14 | 0.28 | 0.80 |
| Triglycerides, mg/dL | 129.7±1.41 | 144.3±9.29 | 136.8±9.7 | 0.12 | 0.47 | 0.57 |
| Chol Rx, % | 17.2 | 15.6 | 16.6 | 0.72 | 0.89 | 0.88 |
| eGFR, mL/min per 1.73 m2 | 89.2±0.25 | 87.1±1.67 | 86.3±1.74 | 0.22 | 0.10 | 0.72 |
| eGFR <60 mL/min per 1.73 m2, % | 4.8 | 9.6 | 12.2 | 0.06 | 0.005 | 0.47 |
| Diabetes mellitus, % | 11.6 | 25.6 | 22.1 | 0.0003 | 0.008 | 0.53 |
| Current smoking, % | 11.7 | 15 | 18.3 | 0.39 | 0.10 | 0.56 |
| hs‐CRP, mg/L | 3.61±0.1 | 4.72±0.64 | 4.78±0.67 | 0.09 | 0.09 | 0.95 |
| IL‐6, pg/mL | 1.53±0.02 | 2.01±0.14 | 1.92±0.14 | 0.0007 | 0.009 | 0.64 |
| D‐dimer, μg/mL | 0.36±0.01 | 0.56±0.09 | 0.48±0.09 | 0.02 | 0.20 | 0.50 |
| GlycA, μmol/L | 379.8±1.1 | 402.4±7.0 | 397.2±7.3 | 0.002 | 0.02 | 0.61 |
Data are given as mean±SD unless otherwise indicated. Serum ICTP and PIIINP levels are given. BMI indicates body mass index; bpm, beats/min; BP Rx, blood pressure–lowering therapy; Chol Rx, cholesterol‐lowering therapy; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate21; HDL‐C, high‐density lipoprotein cholesterol; HF, heart failure; HFpEF, HF with preserved ejection fraction; HFrEF, HF with reduced ejection fraction; HR, heart rate; hs‐CRP, high‐sensitivity C‐reactive protein; ICTP, collagen type I carboxy‐terminal telopeptide; IL‐6, interleukin 6; LDL‐C, low‐density lipoprotein cholesterol; PIIINP, procollagen type III N‐terminal propeptide; and SBP, systolic blood pressure.
N value varies slightly for some variables: LDL‐C, n=3145; IL‐6, n=3117; D‐dimer, n=3182; GlycA, n=3183.