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. 2018 Feb 25;7(5):e008025. doi: 10.1161/JAHA.117.008025

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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No uninephrectomy (UNX)‐induced changes in blood pressure and plasma asymmetric dimethylarginine (ADMA) and l‐citrulline levels in arginase‐2 knockout (Arg‐2^−/−) mice. Arg‐2^−/− mice displayed no significant increase in blood pressure post‐UNX (dashed bars with white background) both in the inactive (A) and in active (B) phases as measured by telemetry. They showed also no changes in plasma levels of ADMA (C) and l‐citrulline (D) compared with sham‐operated mice (dashed bars with gray background). n=9 animals per group.