Table 2.

Results of Cox Proportional Hazard Models for Association of Platelet Aggregation in Platelet‐Rich Plasma With Incident CVD

Platelet Aggregation Measure	Age‐ and Sex‐Adjusted Analysis			Multivariable‐Adjusted Analysis
	HR	95% CI	P Value	HR	95% CI	P Value
Hyperresponders to ADP (yes/no)	1.39a	1.05–1.84a	0.023a	1.26	0.95–1.69	0.11
Hyperresponders to epinephrine (yes/no)	1.01	0.75–1.36	0.97	0.96	0.71–1.30	0.80
Hyporesponders to ADP (yes/no)	1.51	0.89–2.59	0.13	1.33	0.77–2.28	0.31
Hyporesponders to epinephrine (yes/no)	1.10	0.73–1.66	0.65	0.97	0.64–1.46	0.88
ADP, μmol/L
1.0	1.07	0.98–1.17	0.15	1.06	0.97–1.16	0.22
3.0	0.96	0.88–1.05	0.37	0.98	0.90–1.07	0.62
5.0	0.97	0.87–1.08	0.61	0.98	0.88–1.10	0.76
Epinephrine, μmol/L
0.1	1.06	0.94–1.19	0.37	1.01	0.90–1.14	0.88
0.5	1.04	0.94–1.14	0.48	1.04	0.95–1.15	0.41
1.0	0.94	0.86–1.03	0.19	0.95	0.87–1.05	0.30
3.0	0.95	0.84–1.07	0.38	0.98	0.86–1.11	0.72
Collagen lag time (1.9 μg/mL)	1.08	0.97–1.19	0.15	1.06	0.96–1.17	0.24

Incident CVD was defined for time to first event of myocardial infarction, coronary insufficiency, angina pectoris, atherothrombotic brain infarction, coronary heart disease death, intermittent claudication, congestive heart failure, or transient ischemic attack in the absence of a previous manifestation of any of these diseases. CI indicates confidence interval; CVD, cardiovascular disease; and HR, hazard ratio.

^aResults with P<0.05.