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. 2018 Mar 3;7(5):e008522. doi: 10.1161/JAHA.118.008522

Table 3.

Results of Cox Proportional Hazard Models for Association of Platelet‐Rich Plasma Platelet Aggregation With MI or Stroke (Main Analysis), and MI or Stroke or CVD Death (Secondary Analysis)

Platelet Aggregation Measure Age‐ and Sex‐Adjusted Analysis Multivariable‐Adjusted Analysis
HR 95% CI P Value HR 95% CI P Value
Hyperresponders to ADP (yes/no) 1.88a 1.27–2.79a 0.002a 1.68a 1.13–2.50a 0.011a
MI, stroke, or CVD deathb 1.63a 1.13–2.34a 0.008a 1.47a 1.02–2.13a 0.039a
Hyperresponders to epinephrine (yes/no) 1.01 0.64–1.61 0.95 1.00 0.63–1.60 0.99
MI, stroke, or CVD deathb 0.98 0.65–1.48 0.93 0.96 0.64–1.45 0.85
Hyporesponders to ADP (yes/no) 1.50 0.70–3.20 0.30 1.26 0.58–2.70 0.56
MI, stroke, or CVD deathb 1.56 0.80–3.04 0.20 1.32 0.67–2.60 0.42
Hyporesponders to epinephrine (yes/no) 1.03 0.55–1.90 0.94 0.90 0.49–1.69 0.75
MI, stroke, or CVD deathb 1.04 0.60–1.80 0.90 0.90 0.52–1.56 0.71
ADP, 1.0 μmol/L 1.17a 1.02–1.34a 0.025a 1.16a 1.02–1.33a 0.029a
MI, stroke, or CVD deathb 1.11 0.98–1.25 0.09 1.10 0.98–1.24 0.10
ADP 3.0, μmol/L 1.03 0.91–1.18 0.63 1.05 0.92–1.19 0.51
MI, stroke, or CVD deathb 1.02 0.91–1.15 0.70 1.04 0.93–1.16 0.54
ADP, 5.0 μmol/L 1.06 0.90–1.24 0.52 1.07 0.91–1.26 0.42
MI, stroke, or CVD deathb 1.09 0.94–1.25 0.27 1.09 0.95–1.27 0.23
Epinephrine, 0.1 μmol/L 1.03 0.86–1.23 0.75 1.00 0.83–1.19 0.95
MI, stroke, or CVD deathb 1.04 0.89–1.21 0.63 1.00 0.85–1.17 0.97
Epinephrine, 0.5 μmol/L 1.05 0.91–1.20 0.55 1.07 0.92–1.23 0.39
MI, stroke, or CVD deathb 1.01 0.90–1.15 0.83 1.03 0.91–1.17 0.62
Epinephrine, 1.0 μmol/L 0.91 0.79–1.05 0.19 0.92 0.80–1.07 0.28
MI, stroke, or CVD deathb 0.91 0.80–1.03 0.12 0.92 0.81–1.04 0.19
Epinephrine, 3.0 μmol/L 1.05 0.87–1.26 0.62 1.08 0.90–1.31 0.41
MI, stroke, or CVD deathb 1.01 0.86–1.19 0.87 1.05 0.89–1.24 0.55
Collagen lag time (1.9 μg/mL) 1.05 0.91–1.22 0.49 1.04 0.90–1.21 0.58
MI, stroke, or CVD deathb 1.07 0.94–1.22 0.30 1.06 0.93–1.20 0.42

Incident MI or stroke was defined as time to first event of nonfatal MI or atherothrombotic brain infarction, excluding fatal events and other CVD definitions. CI indicates confidence interval; CVD, cardiovascular disease; HR, hazard ratio; and MI, myocardial infarction.

a

Results with P<0.05.

b

Secondary analyses including CVD death as outcome.