Table 4.

Nine common canonical pathways identified by Ingenuity Pathway Analysis based on genes that were differentially expressed in FFSS-treated podocytes at End-FFSS, Post-2 h FFSS, and Post-24 h FFSS compared with control

	P Value
Common Canonical Pathways on IPA	End-FFSS	Post-2 h FFSS	Post-24 h FFSS
Cholecystokinin/gastrin-mediated signaling	0.010	0.030	0.044
MAPK/ERK signaling	0.033	0.006	0.003
Glioma invasiveness signaling	0.036	0.048	0.034
Glucocorticoid receptor signaling	0.007	<0.001	0.019
GNRH signaling	0.001	0.001	0.027
LPS-stimulated MAPK signaling	0.014	<0.001	0.013
Production of nitric oxide and reactive oxygen species in macrophages	0.009	<0.001	0.029
Salvage pathways of pyrimidine ribonucleotides	0.007	<0.001	0.013
Thrombopoietin signaling	0.033	0.015	0.037

Ingenuity Pathway Analysis (IPA) based on genes that were differentially expressed (P < 0.01) in fluid flow shear stress (FFSS)-treated podocytes compared with control. GNRH, gonadotropin-releasing hormone.