Fig. 4.
Fenofibrate slows kidney cyst growth in Pkd1RC/RC mice. Kidney MRIs and histological analysis were performed to determine whether fenofibrate treatment affected PKD progression in Pkd1RC/RC mice. A and B: representative T2-weighted MRI images, three-dimensional reconstruction of the MRI and hematoxylin and eosin (H&E)-stained sections of the same control and fenofibrate-treated mice are shown. C and D: quantification showed that MRI-assessed total kidney volume and total cyst volume was reduced in fenofibrate-treated compared to control-treated Pkd1RC/RC mice. E and F: consistent with the MRI analysis, kidney-weight-to-body-weight ratio and histological cyst index were reduced in fenofibrate-treated compared to control-treated Pkd1RC/RC mice. G: biochemical analysis showed that serum creatinine levels were reduced in fenofibrate-treated compared to control-treated Pkd1RC/RC mice. Fenofibrate (feno) group, n = 8 and control (Ctl) group, n = 8. Error bars represent means ± SE.