Table 1.

Chow-fed mice statistical outcomes

	Binge	Time	Binge × Time
Terminal body weight	P = 0.38	P = 0.59	P = 0.23
Serum alcohol	P < 0.00*	P = 0.31	P = 0.29
Markers of intestinal permeability
Lactulose	P < 0.00*	P = 0.53	P = 0.25
Mannitol	P < 0.00*	P = 0.53	P = 0.17
Sucralose	P < 0.00*	P < 0.00*	P < 0.00*
LPS	P = 0.32	P = 0.02*	P = 0.60
LBP	P = 0.10	P = 0.91	P = 0.09
Markers of liver pathology
Steatosis	P < 0.00*†	P = 0.08†	NA†
Inflammation	P = 0.32†	P = 0.10†	NA†
MPO	P = 0.62	P = 0.50	P = 0.80
ALT	P = 0.03*	P = 0.89	P = 0.76
AST	P < 0.00*	P = 0.23	P = 0.93

LPS, lipopolysaccharide; LBP; lipopolysaccharide-binding protein; MPO, myeloperoxidase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; NA, not applicable. Chow-fed mice exhibit treatment-induced effects on body weight, serum alcohol concentrations, markers of intestinal permeability, and markers of liver pathology. Between 5 and 10 mice were included at each treatment group at each time point. Data were analyzed using a 2-way ANOVA, except where indicated.

^†Data were analyzed via a nonparametric Kruskal-Wallis test;

^*P < 0.05.