Fig. 8.

Bioinformatics analysis of AQP2 interactome. A and B: depicted are the enriched Gene Ontology (GO) terms Biological Process (A) and Molecular Function (B) in AQP2 interactome relative to rat IMCD transcriptome as determined by DAVID analysis. C: AQP2-interacting protein domain analysis. Interacting proteins (yellow circle) are linked to their interacting or structural domains (blue hub). Protein domains were extracted using ABE and AbDesigner (see methods). Domain names: CaM, calmodulin; EF-h, EF-hand; PIR, protein PIR; PLEC, plectin repeat; PSI, plexin repeat; RRM, RNA recognition motif; SPEC, spectrin repeats; b, binding.