Table 2.
Fitting parameters for INa properties
| gmax, mS/µF | V1/2G, mV | kG, mV | R2 | P | ||
|---|---|---|---|---|---|---|
| INa conductance | ||||||
| WT | 0.54 ± 0.02 | −43.9 ± 0.7 | 3.61 ± 0.6 | 0.81 | <0.0001 | |
| NICD | 0.38 ± 0.01 | −42.4 ± 0.8 | 3.98 ± 0.7 | 0.79 | ||
| INa activation | ||||||
| WT | −42.8 ± 0.3 | 4.1 ± 0.3 | 0.94 | 0.559 | ||
| NICD | −42.0 ± 0.4 | 4.3 ± 0.4 | 0.89 | |||
| INa steady-state inactivation | ||||||
| WT | −74.3 ± 0.2 | 4.8 ± 0.2 | 0.98 | 0.0419 | ||
| NICD | −70.9 ± 0.2 | 4.4 ± 0.2 | 0.98 | |||
Values are means ± SE. INa, fast Na+ current; gmax, maximal conductance; V1/2G, potential at which conductance is halfway between 0 and gmax; kG, slope of the conductance curve; WT, wild type; NICD, Notch1 intracellular domain.