Table 2.
Validated mature miRNAs relevant to renal fibrosis
| Family | Target | MiRNA |
|---|---|---|
| Antifibrotic | ||
| Let-7 | COL1A2 | hsa-let-7g-5p |
| FN1 | hsa-let-7g-5p | |
| JAG1 | hsa-let-7b-5p, hsa-miR-98-5p | |
| SMAD2 | hsa-let-7g-5p | |
| THBS1 | hsa-let-7a-5p, hsa-let-7b-5p, hsa-let-7c-5p, hsa-let-7d-5p, hsa-let-7e-5p, hsa-let-7f-5p, hsa-let-7g-5p, hsa-let-7i-5p, hsa-miR-98-5p | |
| Thbs1 | mmu-let-7b-5p | |
| Zeb2 | mmu-let-7b-5p | |
| ZEB2 | hsa-let-7d-5p | |
| MiR-29 | Spry1 | mmu-miR-29c-3p |
| TGFB1 | hsa-miR-29b-3p | |
| Tgfb1 | mmu-miR-29b-2-5p | |
| Col1a2 | mmu-miR-29a-3p, mmu-miR-29b-3p | |
| LAMC1 | hsa-miR-29c-3p | |
| LAMC2 | hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p | |
| Fbn1 | mmu-miR-29a-3p, mmu-miR-29b-3p | |
| FBN1 | hsa-miR-29a-3p, hsa-miR-29b-3p, hsa-miR-29c-3p | |
| Eln | mmu-miR-29a-3p, mmu-miR-29b-3p, | |
| Itgb1 | rno-miR-29b-3p | |
| MiR-126 | EGFL7 | hsa-miR-126-3p |
| VEGFA | hsa-miR-126-3p | |
| IRS1 | hsa-miR-126-3p | |
| Irs1 | mmu-miR-126a-3p | |
| SPRED1 | hsa-miR-126-3p | |
| Spred1 | mmu-miR-126a-3p | |
| CXCL12 | hsa-miR-126-5p, hsa-miR-126-3p | |
| AKT2 | hsa-miR-126-3p | |
| MiR-30 | TP53 | hsa-miR-30a-5p, hsa-miR-30b-5p, hsa-miR-30c-5p, hsa-miR-30d-5p, hsa-miR-30e-5p |
| Tp53 | rno-miR-30a-5p, rno-miR-30b-5p, rno-miR-30c-5p, rno-miR-30d-5p, rno-miR-30e-5p | |
| NOTCH1 | hsa-miR-30a-5p, hsa-miR-30b-5p, hsa-miR-30c-5p, hsa-miR-30d-5p, hsa-miR-30e-5p | |
| Ucp2 | mmu-miR-30e-5p | |
| Ctgf | rno-miR-30c-5p | |
| ZEB2 | hsa-miR-30c-5p, hsa-miR-30e-5p | |
| MiR-146a | TRAF6 | hsa-miR-146a-5p |
| Traf6 | mmu-miR-146a-5p, rno-miR-146a-5p | |
| IRAK1 | hsa-miR-146a-5p | |
| Irak1 | mmu-miR-146a-5p, rno-miR-146a-5p | |
| SMAD2 | hsa-miR-146a-5p | |
| Smad4 | rno-miR-146a-5p | |
| TLR4 | hsa-miR-146a-5p, hsa-miR-146b-5p | |
| MiR-34c | NOTCH1 | hsa-miR-34c-5p |
| NOTCH4 | hsa-miR-34c-5p | |
| Profibrotic | ||
| MiR-21 | PPARA | hsa-miR-21-5p |
| MMP9 | hsa-miR-21-5p | |
| Mmp9 | mmu-miR-21a-5p | |
| MMP2 | hsa-miR-21-5p | |
| PTEN | hsa-miR-21-5p | |
| Pten | mmu-miR-21a-5p, rno-miR-21-5p | |
| AKT2 | hsa-miR-21-5p | |
| SMAD7 | hsa-miR-21-5p | |
| Smad7 | mmu-miR-21a-5p | |
| DDAH1 | hsa-miR-21-5p | |
| TGFB1 | hsa-miR-21-5p | |
| MiR-214 and -199 | PTEN | hsa-miR-214-3p |
| AKT1 | hsa-miR-199a-3p | |
| MiR-433 | AZIN1 | hsa-miR-433-3p |
| MAPK8 | hsa-miR-433-3p | |
| MiR-132 and -212 | MAPK1 | hsa-miR-132-3p |
| Foxo3 | rno-miR-132-3p, rno-miR-212-3p, mmu-miR-212-3p, mmu-miR-132-3p | |
| Ep300 | mmu-miR-132-3p | |
| Mmp9 | rno-miR-132-3p, mmu-miR-212-3p, mmu-miR-132-3p | |
| MiR-324 | Zeb2 | mmu-miR-324-3p |
| MiR-382 | Klk5 | mmu-miR-382-5p |
Source: from miRTarBase (http://mirtarbase.mbc.nctu.edu.twphp/index.php).