Table 5.

Intramyocellular [¹³C₁₆]16:0 ceramide enrichment and fractional contributions of plasma palmitate to intramyocellular ceramide during continuous intravenous infusion of [U-¹³C]palmitate

	Postprandial Period
Time from baseline	1.5 h	6.5 h	P Value
Plasma [U-13C]palmitate enrichment	0.064 ± 0.035	0.068 ± 0.036
[13C16]16:0 ceramide enrichment
SS fraction	0.009 (0.000–0.015)	0.014 (0.008–0.021)	0.0024
IMF fraction	0.002 (0.000–0.005)	0.004 (0.000–0.007)	0.0025
Fractional contribution of plasma palmitate to ceramide, %
SS fraction	9.4 (0.0–23.5)*	19.9 (5.8–39.5)†	0.0043
IMF fraction	4.1 (0.0–8.7)	7.1 (0.0–15.2)	0.0030

Data are shown as means ± SD or median (interquartile range). Plasma [U-¹³C]palmitate enrichments at 1.5 h and 6.5 h represent mean values until the first biopsy and the mean values from time 0 until the second biopsy, respectively. Analyzed by Wilcoxon signed rank test.

^*Significantly different from fractional contribution of plasma palmitate in IMF at the same time point (P = 0.0143);

^†Significantly different from fractional contribution of plasma palmitate in IMF at the same time point (P = 0.0002).