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. 2018 Mar 23;5:2. doi: 10.1186/s40734-018-0069-3

Fig. 1.

Fig. 1

Subcortical volume change over time. Individual volumes over time in premanifest HD for all seven subcortical structures. Disease duration (years) was calculated for converters with time of conversion based on the Diagnostic Confidence Level (DCL) of 4. For non-converters, estimated time to disease onset was calculated using the survival analysis formula of Langbehn et al. [13]. ICV: Intra-Cranial Volume